奥拉西坦注射液联合康复训练治疗脑卒中后血管性认知障碍的疗效观察  

Efficacy observation of oxiracetam injection combined with rehabilitation training in the treatment of vascular cognitive impairment after stroke

作　　者：孟繁星 MENG Fan-xing(Department of pharmacy,Fushun Third Hospital,Fushun 113000,China)

机构地区：[1]抚顺市第三医院药剂科,113000

出　　处：《中国现代药物应用》2023年第22期155-157,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析奥拉西坦注射液联合康复训练治疗脑卒中后血管性认知障碍的疗效。方法70例脑卒中后血管性认知障碍患者,按照随机数字表法分为对照组和观察组,每组35例。对照组给予奥拉西坦注射液治疗,观察组在对照组基础上增加康复训练。比较两组住院时间,治疗前后认知功能[简易智力状态检查量表(MMSE)评分、蒙特利尔认知量表(MoCA)评分]、日常生活活动能力[日常生活能力评定量表(BI)评分]及疗效。结果观察组住院时间(9.19±2.13)d短于对照组的(12.81±3.56)d,差异有统计学意义(P<0.05)。治疗后,两组MMSE评分、MoCA评分、BI评分均明显高于本组治疗前,且观察组MMSE评分、MoCA评分、BI评分分别为(25.51±3.21)、(27.56±3.21)、(89.45±3.35)分,显著高于对照组的(22.51±2.34)、(20.56±3.01)、(73.15±3.21)分,差异有统计学意义(P<0.05)。观察组总有效率97.14%高于对照组的74.29%,差异有统计学意义(P<0.05)。结论奥拉西坦注射液联合康复训练对脑卒中后血管性认知障碍的治疗效果确切,可促使患者认知功能得到改善,并提高患者日常生活活动能力,值得推广和应用。Objective To analyze the efficacy of oxiracetam injection combined with rehabilitation training in the treatment of vascular cognitive impairment after stroke.Methods A total of 70 patients with vascular cognitive impairment after stroke were divided into a control group and an observation group according to the random numerical table,with 35 cases in each group.The control group was treated with oxiracetam injection,and the observation group was given rehabilitation training on the basis of the control group.Both groups were compared in terms of hospital stay,cognitive function[mini-mental state examination(MMSE)score,Montreal cognitive scale(MoCA)score],activities of daily living[Barthel index(BI)score]before and after treatment and efficacy.Results The hospital stay of(9.19±2.13)d in the observation group was shorter than that of(12.81±3.56)d in the control group,and the difference was statistically significant(P<0.05).After treatment,MMSE score,MoCA score and BI score in both groups were significantly higher than those before treatment in this group;MMSE score,MoCA score and BI score in the observation group were(25.51±3.21),(27.56±3.21)and(89.45±3.35)points,which were significantly higher than those of(22.51±2.34),(20.56±3.01)and(73.15±3.21)points in the control group;the differences were statistically significant(P<0.05).The total effective rate of 97.14%in the observation group was higher than that of 74.29%in the control group,and the difference was statistically significant(P<0.05).Conclusion Oxiracetam injection combined with rehabilitation training is effective in the treatment of vascular cognitive impairment after stroke,and can improve patients'cognitive function and their activities of daily living,which is worthy of popularization and application.

关 键 词：脑卒中 血管性认知障碍 奥拉西坦注射液 康复训练 疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.1[医药卫生—临床医学]