乌司奴单抗治疗狭窄型克罗恩病1例报道及文献回顾  

Ustekinumab in the treatment of stenosis Crohn's disease:A case report and literature review

作　　者：邵晓晓[1] 史睿昕 方晔 王伟中 蒋益[1] SHAO Xiaoxiao;SHI Ruixin;FANG Ye;WANG Weizhong;JIANG Yi(Department of Gastroenterology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China;不详)

机构地区：[1]温州医科大学附属第二医院育英儿童医院消化内科,浙江温州325000 [2]温州医科大学第二临床医学院,浙江温州325000

出　　处：《中华全科医学》2023年第12期2169-2172,2176,共5页Chinese Journal of General Practice

基　　金：浙江省温州市科技计划项目(Y2020285);贺林院士工作站科研基金项目(19331101)。

摘　　要：克罗恩病(Crohn's disease,CD)是一种病因不明的慢性肉芽肿性疾病,可累及从口腔至肛门消化道的任何部位。CD常伴有多种并发症,如肠腔狭窄、肠瘘、脓肿、穿孔等,其中肠腔狭窄是最常见的并发症,但目前临床上尚缺乏根治CD肠腔狭窄的有效方法。近期研究发现乌司奴单抗(ustekinumab,UST)可以通过抑制IL-12和IL-23介导的细胞信号传导、激活和下游炎性细胞因子产生,从而减轻CD患者肠道慢性炎症相关性狭窄。本文对温州医科大学附属第二医院收治的1例CD合并肠腔狭窄的患者采用UST治疗并取得了良好的治疗效果,现报道如下并作相关文献回顾。Crohn's disease(CD)is a chronic granulomatous disease of unknown etiology that can affect any part of the alimentary tract from the mouth to the anus.CD is often accompanied by a variety of complications,such as intestinal lumen stenosis,intestinal fistula,abscess and perforation.Intestinal lumen stenosis is the most common complication,and there is still a lack of effective methods for the radical treatment of CD intestinal lumen stenosis.Recent studies have found that ustekinumab(UST)attenuates chronic inflammation-associated stenosis in the intestinal tract of CD patients by inhibiting IL-12 and IL-23-mediated cell signaling,activation,and downstream inflammatory cytokine production.In this paper,a case of CD complicated with intestinal stenosis admitted to the Second Affiliated Hospital of Wenzhou Medical University was treated with UST and achieved good therapeutic effect.The case is reported as follows and relevant literature is reviewed.

关 键 词：克罗恩病 肠狭窄 炎症性肠病 乌司奴单抗 

分 类 号：R574[医药卫生—消化系统]