姜黄素联合放疗对老年性食管癌放疗增敏的临床疗效  

Clinical efficacy of curcumin combined with radiotherapy on radiotherapy sensitization of senile esophageal cancer

作　　者：石玲[1] 梅耀国 朱学雨 段训凰[1] 汪波 SHI Ling;MEI Yaoguo;ZHU Xueyu;DUAN Xunhuang;WANG Bo(Department of Oncology,Jiujiang NO.1 People's Hospital,Jiujiang,Jiangxi,332000,China;Department of Oncology,Jiujiang Hospital of Traditional Chinese Medicine,Jiujiang,Jiangxi,332099,China)

机构地区：[1]九江市第一人民医院肿瘤科,江西九江332000 [2]九江市中医医院肿瘤科,江西九江332099

出　　处：《当代医学》2023年第15期38-40,共3页Contemporary Medicine

基　　金：九江市重点研发计划项目(S2021ZDYF208)。

摘　　要：目的探讨姜黄素联合放疗对老年性食管癌放疗增敏的临床疗效。方法选取2018年1月至2021年8月九江市第一人民医院收治的60例未经手术、化疗的初治老年性食管癌患者作为研究对象,按照随机数字表法分为实验组与对照组,各30例。对照组采用根治性放疗,实验组在对照组基础上联合姜黄素治疗,比较两组临床疗效(疾病控制率、客观缓解率)、不同时间肿瘤标志物[癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、糖类抗原125(CA125)]水平。结果实验组疾病控制率、客观缓解率均高于对照组,差异有统计学意义(P<0.05)。两组CEA、CA19-9、CA125水平组间、时间、交互比较差异有统计学意义(P<0.05)。组内比较:两组治疗后各时间CEA、CA19-9、CA125水平均低于前一时间点,差异有统计学意义(P<0.05)。组间比较:治疗前,两组CEA、CA19-9、CA125水平比较差异无统计学意义;治疗1个月、治疗结束后1个月,实验组CEA、CA19-9、CA125水平均低于对照组,差异有统计学意义(P<0.05)。结论姜黄素联合放疗对老年性食管癌放疗增敏的临床疗效显著,可有效提高患者疾病控制率、客观缓解率,降低其机体肿瘤标志物水平,值得临床推广应用。Objective To explore the clinical efficacy of curcumin combined with radiotherapy on radiotherapy sensitization of senile esophageal cancer.Methods 60 patients with initially treated senile esophageal cancer without surgery or radiotherapy treated in the Jiujiang NO.1 People's Hospital from January 2018 to August 2021 were selected as the research subjects,they were divided into the experimental group and the control group according to random number table method,with 30 cases in each group.The control group was treated with radical radiotherapy,and the experimental group was treated with curcumin on the basis of the control group,the clinical efficacy(disease control rate,objective remission rate)and the levels of tumor markers(carcinoembryonic antigen[CEA],carbohydrate antigen 19-9[CA19-9]and carbohydrate antigen 125[CA125])were compared between the two groups.Results The disease control rate and objective remission rate in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were significant differences in the levels of CEA,CA19-9 and CA125 between two groups of group,time points and interaction(P<0.05).Comparison within the group:the levels of CEA,CA19-9 and CA125 of the two groups at each time after treatment were lower than the previous time point,and the differences were statistically significant(P<0.05).Comparison between the groups:before treatment,there was no significant difference in CEA,CA19-9 and CA125 levels between the two groups;after 1 month of treatment and 1 month after treatment,CEA,CA19-9 and CA125 levels in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Curcumin combined with radiotherapy has significant clinical effect on radiotherapy sensitization of senile esophageal cancer,which can effectively improve the disease control rate and objective remission rate of patients,and reduce the level of tumor markers in the body,which

关 键 词：老年性食管癌 姜黄素 根治性放疗 疾病控制率 客观缓解率 

分 类 号：R735.1[医药卫生—肿瘤]