TIPE2、Ki-67在子宫内膜癌组织中的表达及其与病理特征的关系  

Expression of TIPE2,Ki-67 in endometrial cancer tissues and their relationship with pathological features

作　　者：周丽媛 施喆 刘悦君 刘明月 郭晓慧 郝旭峰 李静霞[1] 安欣[6] ZHOU Liyuan;SHI Zhe;LIU Yuejun;LIU Mingyue;GUO Xiaohui;HAO Xufeng;LI Jingxia;AN Xin(Department of Gynecology,Affiliated Hospital of Hebei Engineering University,Hebei Province,Handan056002,China;Department of General Surgery,Affiliated Hospital of Hebei Engineering University,Hebei Province,Handan056002,China;Department of Oncology,Handan Central Hospital,Hebei Province,Handan056002,China;Department of General Surgery,Handan Central Hospital,Hebei Province,Handan056002,China;Ward One,Department of Gynecology,Hebei Provincial Cixian People’s Hospital,Hebei Province,Handan056002,China;Department of Pathology,Handan First Hospital,Hebei Province,Handan056002,China)

机构地区：[1]河北工程大学附属医院妇科,河北邯郸056002 [2]河北工程大学附属医院普通外科,河北邯郸056002 [3]河北省邯郸市中心医院肿瘤科,河北邯郸056002 [4]河北省邯郸市中心医院普外科,河北邯郸056002 [5]河北省磁县人民医院妇一科,河北邯郸056002 [6]河北省邯郸市第一医院病理科,河北邯郸056002

出　　处：《中国医药导报》2023年第29期15-19,共5页China Medical Herald

基　　金：河北省医学科学研究课题(20220667)。

摘　　要：目的分析免疫负调控分子TIPE2、Ki-67在子宫内膜癌患者组织中的表达及与其病理特征的关系。方法选取2018年1月至2020年1月河北工程大学附属医院(以下简称“我院”)妇科就诊的子宫内膜癌患者60例为病例组,另选取同期我院就诊的子宫内膜非典型增生患者60例为对照组。比较两组TIPE2、Ki-67表达水平;比较不同病理特征子宫内膜癌患者组织中TIPE2、Ki-67表达水平;分析TIPE2、Ki-67表达与病理特征的相关性。结果病例组TIPE2阴性率、Ki-67阳性率高于对照组,差异有统计学意义(P<0.05)。不同国际妇产科联盟(FIGO)分期、组织学分级、肌层浸润程度和淋巴结转移情况的子宫内膜癌患者TIPE2阴性率、Ki-67阳性率比较,差异有统计学意义(P<0.05);不同病理类型、肿瘤直径的子宫内膜癌患者TIPE2阴性率、Ki-67阳性率比较,差异无统计学意义(P>0.05)。TIPE2阴性、Ki-67阳性表达与FIGO分期、组织学分级、肌层浸润程度、淋巴结转移呈正相关(rs>0,P<0.05)。结论子宫内膜癌患者TIPE2阴性率、Ki-67阳性率较高,可用于评估癌细胞发生浸润、转移的潜能及病理分期、组织学分级情况。Objective To analyze the expression of TIPE2 and Ki-67 in the tissues of patients with endometrial cancer and their relationship with pathological features.Methods From January 2018 to January 2020,60 patients with endometrial cancer treated in the Affiliated Hospital of Hebei Engineering University(hereinafter referred to as“our hospital”)were selected as case group,and another 60 patients with endometrial atypical hyperplasia treated in our hospital during the same period were selected as control group.The expression levels of TIPE2 and Ki-67 were compared between two groups;the expression levels of TIPE2 and Ki-67 in endometrial carcinoma patients with different pathological characteristics were compared;and the correlation of the expression of TIPE2 and Ki-67 with pathological features was analyzed.Results The negative rate of TIPE2 and the positive rate of Ki-67 in case group were higher than those in the control group,and the differences were statistically significant(P<0.05).The negative rate of TIPE2 and the positive rate of Ki-67 in patients with endometrial cancer were statistically significant in different Federation International of Gynecology and Obstetrics(FIGO)stages,histological grades,degree of muscular invasion,and lymph node metastasis(P<0.05);there were no significant differences in the negative rate of TIPE2 and the positive rate of Ki-67 with different pathological types and tumor diameters in patients with endometrial cancer(P>0.05).The expression of TIPE2 negative and Ki-67 positive were positively correlated with FIGO stage,histological grade,degree of muscle infiltration,and lymph node metastasis(rs>0,P<0.05).Conclusion The negative rate of TIPE2 and the positive rate of Ki-67 in patients with endometrial carcinoma is high,which can be used to evaluate the potential of invasion and metastasis,pathological stage,and histological grade of cancer cells.

关 键 词：子宫内膜癌 免疫负调控分子 TIPE2 KI-67 病理特征 

分 类 号：R737.33[医药卫生—肿瘤]