前列腺癌组织中长链非编码RNA OSTN-AS1、微RNA-1207-3p的表达与临床病理参数和预后的关系  

Relationship between the expression of long non-coding RNA OSTN-AS1 and microRNA-1207-3p in prostate cancer tissues and clinicopathological parameters and prognosis

作　　者：李旭瑜 张玉 张海建 韩志兴 纪世琪 刘庆军 LI Xuyu;ZHANG Yu;ZHANG Haijian;HAN Zhixing;JI Shiqi;LIU Qingjun(Department of Urology Surgery,Beijing Ditan Hospital Capital Medical University,Beijing100015,China)

机构地区：[1]首都医科大学附属北京地坛医院泌尿外科,北京100015

出　　处：《中国医药导报》2023年第29期107-111,共5页China Medical Herald

基　　金：首都卫生发展科研项目(首发2018-2-2201)。

摘　　要：目的研究前列腺癌(PCa)组织中长链非编码RNA(lncRNA)OSTN-AS1、微RNA(miR)-1207-3p的表达及与临床病理参数和预后的关系。方法选取自2015年1月至2017年12月于首都医科大学附属北京地坛医院收治的102例PCa患者。采用实时荧光定量PCR检测癌组织和癌旁组织中lncRNA OSTN-AS1、miR-1207-3p表达,分析两者表达与临床病理特征关系。根据癌组织lncRNA OSTN-AS1、miR-1207-3p表达均值,将患者分为lncRNA OSTN-AS1低表达组(<3.26,50例)和高表达组(≥3.26,52例),miR-1207-3p低表达组(<3.69,49例)和高表达组(≥3.69,53例)。随访5年,分析lncRNA OSTN-AS1、miR-1207-3p与预后的关系。Cox回归分析影响PCa患者预后的因素。结果PCa组织中lncRNA OSTN-AS1、miR-1207-3p表达高于癌旁组织,差异有统计学意义(P<0.05)。不同TNM分期、Gleason评分、淋巴结转移的PCa组织中LncRNA OSTN-AS1、miR-1207-3p表达水平比较,差异有统计学意义(P<0.05)。lncRNA OSTN-AS1高表达组5年累积生存率低于lncRNA OSTN-AS1低表达组(P<0.05)。miR-1207-3p高表达组5年累积生存率低于miR-1207-3p低表达组(P<0.05)。Cox回归分析显示,肿瘤TNM分期Ⅲ期、Gleason评分>7分、淋巴结转移、lncRNA OSTN-AS1高表达、miR-1207-3p高表达是影响PCa患者预后的独立危险因素(P<0.05)。结论PCa组织中lncRNA OSTN-AS1、miR-1207-3p表达升高,两者表达与Gleason评分、TNM分期、淋巴结转移及预后生存有关,参与PCa的肿瘤进展。Objective To investigate the expression of long non-coding RNA(lncRNA)OSTN-AS1 and microrNA(miR)-1207-3p in prostate cancer(PCa)tissues and their relationship with clinicopathological parameters and prognosis.Methods A total of 102 PCa patients admitted to Beijing Ditan Hospital Capital Medical University from January 2015 to December 2017 were selected.Real-time fluorescence quantitative PCR was used to detect the expression of lncRNA OSTN-AS1 and miR-1207-3p in cancer tissues and adjacent tissues,and the relationship between the expression and clinicopathological characteristics was analyzed.According to the mean expression of lncRNA OSTN-AS1 and miR-1207-3p in cancer tissues,patients were divided into low lncRNA OSTN-AS1 expression group(<3.26,50 cases)and high lncRNA OSTN-AS1 expression group(≥3.26,52 cases);and low miR-1207-3p expression group(<3.69,49 cases)and high miR-1207-3p expression group(≥3.69,53 cases).Follow-up for five years was conducted to analyze the relationship between lncRNA OSTN-AS1,miR-1207-3p,and prognosis.Cox regression analysis of the factors affecting the prognosis of PCa patients.Results The expressions of lncRNA OSTN-AS1 and miR-1207-3p in PCa tissues were higher than those in paracancer tissues,and the differences were statistically significant(P<0.05).The expression levels of lncRNA OSTN-AS1 and miR-1207-3p in PCa tissues with different TNM stages,Gleason score and lymph node metastasis were statistically significant(P<0.05).The 5-year cumulative survival rate of lncRNA OSTN-AS1 high expression group was lower than that of lncRNA OSTN-AS1 low expression group(P<0.05).The 5-year cumulative survival rate of miR-1207-3p high expression group was lower than that of miR-1207-3p low expression group(P<0.05).Cox regression analysis showed that TNM stageⅢ,Gleason score>seven points,lymph node metastasis,lncRNA OSTN-AS1 high expression,and miR-1207-3p high expression were independent risk factors for the prognosis of PCa patients(P<0.05).Conclusion The expression of lncRNA OSTN-AS1 an

关 键 词：前列腺癌 长链非编码RNA OSTN-AS1 微RNA-1207-3p 

分 类 号：R737.3[医药卫生—肿瘤]