青少年单、双相抑郁障碍患者认知功能与免疫生物标志物和炎症综合评分的相关性  

Association of cognitive function with immune biomarkers and comprehensive inflammatory scores in adolescents with unipolar and bipolar depressive disorder

作　　者：盛东方 杨帆[2] 钟菁 余金鸣 陈贻华 杜宝国 许明智 SHENG Dongfang;YANG Fan;ZHONG Jing;YU Jinming;CHEN Yihua;DU Baoguo;XU Mingzhi(The Second Clinical Medical College,Southern Medical University,Guangdong Province,Guangzhou 510260,China;Guangdong Mental Health Center,Guangdong Provincial People’s Hospital of Southern Medical University Guangdong Academy of Medical Sciences,Guangzhou Province,Guangdong 510180,China;School of Public Health,Southern Medical University,Guangdong Province,Guangzhou 510515,China;Department of Emotional Disorder,Zhongshan Third People’s Hospital,Guangdong Province,Zhongshan 528451,China)

机构地区：[1]南方医科大学第二临床医学院,广东广州510260 [2]南方医科大学附属广东省人民医院广东省医学科学院广东省精神卫生中心,广东广州510180 [3]南方医科大学公共卫生学院,广东广州510515 [4]广东省中山市第三人民医院情感障碍科,广东中山528451

出　　处：《中国医药导报》2023年第28期115-118,131,共5页China Medical Herald

基　　金：广东省广州市科学技术局科研基金项目(201904010326)。

摘　　要：目的探讨青少年单、双相抑郁障碍患者认知功能与免疫生物标志物和炎症综合评分的相关性。方法纳入2020年12月至2021年12月广东省人民医院和广东省中山市第三人民医院收治的青少年单相抑郁障碍患者58例(单相组)和双相抑郁障碍患者41例(双相组)。收集两组临床资料,采用斯特鲁普色词测验、威斯康星卡片分类测验(WCST)、数字广度测验(DST)对其进行认知功能评估。采集两组空腹静脉血,检测C反应蛋白水平,血小板、白细胞、粒细胞、淋巴细胞计数,计算免疫生物标志物和炎症综合评分。比较两组临床资料、认知功能和免疫生物标志物及炎症综合评分,分析青少年单、双相抑郁障碍患者认知功能与免疫生物标志物及炎症综合评分的关系。结果双相组发病年龄、发作次数、家族史阳性占比高于单相组,病程长于单相组,差异有统计学意义(P<0.05)。双相组斯特鲁普色词测验正确数、WCST正确应答百分比、DST评分低于单相组,斯特鲁普色词测验错误数、WCST完成第一个分类所需应答数、免疫生物标志物及炎症综合评分高于单相组,差异有统计学意义(P<0.05)。相关性分析结果显示,双相组斯特鲁普色词测验错误数与免疫生物标志物及炎症综合评分呈正相关(rs>0,P<0.05),WSCT正确应答百分比与免疫生物标志物及炎症综合评分呈负相关(r<0,P<0.05)。结论青少年双相抑郁障碍患者的认知功能损害和炎症改变较单相抑郁障碍患者更严重,且其认知功能与免疫生物标志物及炎症综合评分具有相关性。Objective To explore the correlation between cognitive function,immune biomarkers and inflammation score in adolescents with unipolar and bipolar depressive disorder.Methods A total of 58 adolescent patients with unipolar depressive disorder(unipolar group)and 41 patients with bipolar depressive disorder(bipolar group)admitted to Guangdong Provincial People’s Hospital and Zhongshan Third People’s Hospital of Guangdong Province from December 2020 to December 2021 were included.Clinical data of two groups were collected,and the cognitive function was assessed by Stroop color-word test,Wisconsin card sorting test(WCST),and digital span test(DST).Fasting venous blood of the two groups was collected,C-reactive protein levels,platelet,white blood cell,granulocyte,and lymphocyte counts were detected,and immune biomarkers and comprehensive inflammatory scores were calculated.Clinical data,cognitive function,and immune biomarkers and comprehensive inflammatory score were compared between the two groups to analyze the association between cognitive function and immune biomarkers and comprehensive inflammatory score in adolescents with unipolar and bipolar depression.Results The incidence age,frequency of attacks,and positive family history in bipolar group were higher than those in unipolar group,and the course of disease was longer than that in unipolar group,the differences were statistically significant(P<0.05).The correct number of Stroop color-word test,the percentage of correct WCST response,and the DST score in the bipolar group were lower than those in the unipolar group,while the number of Stroop color-word test errors,the number of responses required for WCST to complete the first classification,and the immune biomarkers and comprehensive inflammatory score were higher than those in the unipolar group,the differences were statistically significant(P<0.05).Correlation analysis showed that the number of Stroop color-word test errors was positively correlated with immune biomarkers and comprehensive inflammatory

关 键 词：单相抑郁 双相抑郁 认知功能 免疫生物标志物和炎症综合评分 

分 类 号：R749.4[医药卫生—神经病学与精神病学]