亚甲基四氢叶酸还原酶基因C677T多态性与非酒精性脂肪性肝病易感性的meta分析  

Meta-analysis of methylene tetrahydrofolate reductase gene C677T polymorphism and susceptibility of non-alcoholic fatty liver disease

作　　者：唐瑾 李星海 张宁 TANG Jin;LI Xinghai;ZHANG Ning(Department of Gastroenterology,Ganzhou People’s Hospital,Jiangxi Province,Ganzhou341000,China;Department of Minimally Invasive Intervention,Ganzhou People’s Hospital,Jiangxi Province,Ganzhou341000,China)

机构地区：[1]江西省赣州市人民医院消化内科,江西赣州341000 [2]江西省赣州市人民医院微创介入科,江西赣州341000

出　　处：《中国医药导报》2023年第31期39-43,共5页China Medical Herald

基　　金：江西省卫生健康委员会科技计划项目(202120011)。

摘　　要：目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与非酒精性脂肪性肝病(NAFLD)易感性之间的关系。方法计算机检索Pub Med、Cochrane Library、万方数据知识服务平台、中国知网、中国生物医学文献数据库和维普网,收集有关MTHFR基因多态性与NAFLD易感性关联研究的文献,检索时限为建库至2023年3月。在T vs C、TT vs CC、TT vs CT+CC、TT+CT vs CC、CT vs CC及TT vs CT基因模型下,以OR值和95%CI为效应指标,应用Stata 12.0软件进行meta分析,并对发表偏倚及敏感性分析进行检验。结果共纳入13项研究,包括5542例NAFLD患者及3699例对照。meta分析结果显示,5种遗传模型中NAFLD发生风险增加[T vs C:OR=1.29,95%CI(1.09~1.52),P=0.003;TT vs CC:OR=1.65,95%CI(1.23~2.23),P=0.001;TT vs CT+CC:OR=1.48,95%CI(1.15~1.91),P=0.003;CT+TT vs CC:OR=1.31,95%CI(1.06~1.62),P=0.013;TT vs CT:OR=1.40,95%CI(1.09~1.80),P=0.009],杂合子模型CT vs CC与NAFLD发生风险无相关性[OR=1.21,95%CI(0.98~1.48),P=0.070]。Egger检验及漏斗图结果显示无发表偏倚(P>0.05)。meta回归分析及敏感性分析未发现明显异质性来源(P>0.05)。结论MTHFR基因C667T多态性与NAFLD具有相关性,基因型为TT者NAFLD的发生风险升高。Objective To investigate the relationship between C677T polymorphism of methylene tetrahydrofolate reductase(MTHFR)gene and susceptibility of non-alcoholic fatty liver disease(NAFLD).Methods PubMed,Cochrane Library,Wanfang Data,CNKI,China Biomedical Literature Database,and VIP were searched by computer to collect literatures on the association between MTHFR gene polymorphism and NAFLD susceptibility.The search time was from the inception to March 2023.In the T vs C,TT vs CC,TT vs CT+CC,TT+CT vs CC,CT vs CC,and TT vs CT gene models,the OR value and 95%CI were used as effect indicators for meta-analysis,and the publication bias and sensitivity analysis were tested by Stata 12.0 software.Results A total of 13 literatures were included,including 5542 patients with NAFLD and 3699 controls.Meta-analysis results showed that the risk of NAFLD was increased in five genetic models(T vs C:OR=1.29,95%CI[1.09-1.52],P=0.003;TT vs CC:OR=1.65,95%CI[1.23-2.23],P=0.001;TT vs CT+CC:OR=1.48,95%CI[1.15-1.91],P=0.003;CT+TT vs CC:OR=1.31,95%CI[1.06-1.62],P=0.013;TT vs CT:OR=1.40,95%CI[1.09-1.80],P=0.009),heterozygote model CT vs CC was not associated with the risk of NAFLD(OR=1.21,95%CI[0.98-1.48],P=0.070).The Egger test and funnel plot results showed no publication bias(P>0.05).Meta-regression analysis and sensitivity analysis did not find significant sources of heterogeneity(P>0.05).Conclusion The polymorphism of MTHFR gene C667T is associated with NAFLD,and TT genotype has an increased risk of NAFLD.

关 键 词：非酒精性脂肪性肝病 亚甲基四氢叶酸还原酶 基因C677T 基因多态性 易感性 META分析 

分 类 号：R575[医药卫生—消化系统]