帕金森病合并不宁腿综合征患者临床特征及影响因素分析  

Analysis of clinical characteristics and influencing factors of patients with Parkinson's disease complicated with restless legs syndrome

作　　者：张永志[1,2,3] 张立庄 刘义晗[1,2] 李艳敏 马晓雯[1] 赵薇 郭记宏 邓倩[4] 顾平 ZHANG Yongzhi;ZHANG Lizhuang;LIU Yihan;LI Yanmi;MA Xiaowen;ZHAO Wei;GUO Jihong;DENG Qian;GU Ping(Department of Neurology,2.Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province;the First Hospital of Hebei Medical University∥Hebei Hospital of Xuanwu Hospital Capital Medical University,Shijiazhuang 050000,Heibei,China;Graduate School of Hebei Medical University,Shijiazhuang 050031,Hebei,China;Wusheng General Hospital,Guang an 638400,Sichuan,China)

机构地区：[1]河北医科大学第一医院∥首都医科大学宣武医院河北医院1.神经内科 [2]河北省脑老化与认知神经科学实验室,河北石家庄050000 [3]河北医科大学研究生学院,河北石家庄050031 [4]武胜县人民医院,四川广安638400

出　　处：《暨南大学学报（自然科学与医学版）》2023年第5期513-520,共8页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：河北省卫生健康委员会科研基金资助项目(20230976);河北省科技厅民生科技专项河北省重点研发计划资助项目(20377721D)。

摘　　要：目的:探讨帕金森病(PD)患者中不宁腿综合征(RLS)的临床特征及危险因素。方法:回顾性分析2019年10月至2022年12月于河北医科大学第一医院诊治的PD患者283例,其中合并RLS 160例,未合并RLS 123例。比较合并RLS组(PD-RLS)和未合并RLS组(PD-NRLS)患者间情绪(HAMD_(24)、HAMA_(14))、认知(MMSE)、睡眠(PQSI)、疲劳(BFI)、快速眼动睡眠行为障碍(RBD)、运动症状(UPDRS-Ⅲ)等因素之间的差异,采用Logistic回归分析影响PD患者合并RLS的危险因素。结果:①伴有抑郁、焦虑、睡眠障碍和RBD的PD患者,其RLS发病率高于对照组(P<0.05)。②与PD-NRLS组比较,PD-RLS组患者年龄较小,而HAMD_(24)、HAMA_(14)、PQSI、BFI、RBD、UPDRS-Ⅲ评分更高(P<0.05)。③在PD患者中,RLS与性别、Hoehn-Yahr分期、MMSE评分不相关(P>0.05);RLS与年龄呈负相关(P<0.05)。④多因素Logistic回归分析结果显示年龄、HAMA_(14)是PD患者发生RLS的独立危险因素。结论:PD患者随着年龄增加,其RLS发病风险降低,而PD伴焦虑的患者应警惕RLS的发生,及早识别RLS并给予及时治疗,可提高PD患者的生活质量。Objective:To analyze the risk factors of non-motor symptoms in patients with Parkinson's disease(PD)with restless leg syndrome(RLS)and to investigate the related risk factors.Methods:Retrospectively collected 283 PD patients treated in the First Hospital of Hebei Medical University from October 2019 to December 2022,including 160 patients with RLS(PD-RLS)and 123 patients without RLS(PD-NRLS).By comparing the differences in mood(HAMD_(24)、HAMA_(14)),cognition(MMSE),sleep(PQSI),fatigue(BFI),rapid eye movement(REM)sleep behavior disorder(RBD)motor symptoms(UPDRS-Ⅲ)and other factors between the RLS group and the non-RLS group.Logistic regression analysis was used to analyze the risk factors affecting RLS in PD patients.Results:①The incidence of anxiety,depression,sleep disorders and RBD in PD-RLS was higher than that in PD-NRLS.②Compared with the PD-NRLS,patients in PD-RLS were younger,but the HAMD_(24),HAMA_(14),PQSI,BFI,RBD and UPDRS-Ⅲlevels were higher(P<0.05).③In PD patients,RLS was not correlated with gender,Hoehn-Yahr stage and MMSE(P>0.05).④Multivariate Logistic regression analysis showed that the age and HAMA_(14)were independent risk factors for RLS in PD patients.Conclusion:In PD patients,with the increase of age,the risk of RLS decreases,whereas the PD patients with anxiety should be alert to the occurrence of RLS.Early identification and treatment of RLS may improve the quality of life in PD patients.

关 键 词：帕金森病 不宁腿综合征 焦虑 抑郁 认知障碍 睡眠质量 

分 类 号：R742.5[医药卫生—神经病学与精神病学]