半月神经节周围注射不同形态和浓度三氧治疗三叉神经痛的疗效研究  

Efficacy of different concentrations of gaseous ozone and ozonated water injection around gasserian ganglion on the patient with trigeminal neuralgia

作　　者：程洁 赵倩男 钱晓焱 方七五[3] 李彤 安建雄 CHENG Jie;ZHAO Qiannan;QIAN Xiaoyan;FANG Qiwu;LI Tong;AN Jianxiong(Institute for Innovation Diagnosis&Treatment in Anesthesiology,School of Anesthesiology,Shandong Second Medical University,Department of Anesthesiology,Pain&Sleep Medicine,Affiliated Hospital of Shandong Second Medical University,Weifang 261000,China;Savaid Medical School,University of Chinese Academy of Sciences,Beijing 100012,China;Department of Anesthesiology,Pain and Sleep Medicine,Aviation General Hospital of China Medical University&Beijing Institute of Translational Medicine,Chinese Academy of Sciences,Beijing 100012,China;Department of Pain Medicine,The First People's Hospital of Lanzhou,Lanzhou 730050,China)

机构地区：[1]山东第二医科大学麻醉创新诊疗研究院&麻醉学院暨附属医院麻醉、疼痛与睡眠医学中心,潍坊261000 [2]中国科学院大学存济医学院,北京100012 [3]中国医科大学航空总医院麻醉、疼痛与睡眠医学中心,北京100012 [4]兰州市第一人民医院疼痛科,兰州730050

出　　处：《中国疼痛医学杂志》2023年第12期908-913,共6页Chinese Journal of Pain Medicine

基　　金：首都医学发展基金(202036101);医用三氧水制作和临床应用科技成果转化示范(YDZX2022092);甘肃省自然科学基金(21JR1RA189)。

摘　　要：目的:比较不同形态和浓度三氧半月神经节注射治疗三叉神经痛的疗效。方法:收集2016年11月至2021年11月航空总医院与山东第二医科大学附属医院因三叉神经痛接受治疗的病人诊疗信息,按接受三氧注射的不同形态和浓度分为23μg/ml液态三氧组23例,30μg/ml气态三氧组31例,40μg/ml气态三氧组17例;治疗后1周、6个月和1年进行随访。采用视觉模拟评分法(visual analogue scale,VAS)评分、巴罗神经学研究所(Barrow neurological institute,BNI)疼痛评分、von Frey试验评估病人疼痛程度和面部触觉。结果:与治疗前相比,三组在不同时间点的VAS评分和BNI评分均显著降低,治疗后1周30μg/ml气态三氧组VAS评分和BNI评分显著低于其余两组,治疗后6个月和1年组间比较差异无统计学意义。与治疗前相比,三组术后von Frey值显著降低(P<0.05),但组间比较差异无统计学意义。23μg/ml液态三氧注射治疗后未发现明显的并发症。结论:23μg/ml液态三氧、30μg/ml和40μg/ml气态三氧半月神经节注射治疗均可显著缓解三叉神经痛。23μg/ml液态三氧注射治疗的潜在并发症风险小,临床应用更为安全。Objective:This study aimed to assess the effects of different concentrations of gaseous ozone and ozonated water injection around gasserian ganglion on the patient with trigeminal neuralgia.Methods:Collected the data of patients who suffered from trigeminal neuralgia from November 2016 to November 2021 in the Aviation General Hospital and the Affiliated Hospital of Shandong Second Medical University,then divided into 3 groups 23μg/ml ozonated water injection group(23 patients),30μg/ml gaseous ozone injection group(31 patients),40μg/ml gaseous ozone injection group(17 patients).The therapeutic efficacy was evaluated via visual analogue scale(VAS),Barrow neurological institute(BNI)pain score and tactile sensation at pre-treatment and 1 week,6 months,1 year,post-treatment.Results:The VAS and BNI scores in the three groups at different time points were significantly lower than pre-treatment.Compared with 23μg/ml ozonated water injection and 40μg/ml gaseous ozone injection groups,the VAS,and BNI scores of the 30μg/ml gaseous ozone injection group were lower 1 week after treatment.Similarly,the tactile sensation was significantly decreased at post-treatment compared to pre-treatment(P<0.05).However,there was no statistical difference among the three groups,and no significant complications were observed after 23μg/ml ozonated water injection.Conclusion:23μg/ml ozonated water injection,30μg/ml gaseous ozone injection and 40μg/ml gaseous ozone injection are effective therapies for treating TN.23μg/ml ozonated water injection has a lower risk of potential complications and is safer in clinical applications.

关 键 词：三叉神经痛 气态三氧 液态三氧 半月神经节 三氧治疗 

分 类 号：R745.11[医药卫生—神经病学与精神病学]