^(18)F-FDG联合^(11)C-CFT PET显像分析帕金森病的价值  

Value of ^(18)F-FDG combined with ^(11)C-CFT PET imaging in analyzing Parkinson's disease

作　　者：那孜木古丽·木塔尔别克 张奇洲[1] 秦永德[1] 李毓斌[1] 张磊[1] NAZIMUGULI·Mutaerbieke;ZHANG Qizhou;QIN Yongde;LI Yubin;ZHANG Lei(Department of Nuclear Medicine,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院核医学科,新疆乌鲁木齐830054

出　　处：《分子影像学杂志》2023年第6期964-969,共6页Journal of Molecular Imaging

基　　金：新疆维吾尔自治区科技计划项目(201417101)。

摘　　要：目的 分析^(18)氟-氟代脱氧葡萄糖(^(18)F-FDG)和^(11)C-甲基-N-2β-甲基酯-3β-(4-氟-苯基)托烷(^(11)C-CFT)PET显像联合诊断、病情评价、鉴别诊断帕金森病(PD)的应用价值。方法 选取我院20^(18)年9月~2022年3月收治的107例根据临床症状和口服美多芭有效性初步诊断为PD的患者作为PD组,另选取43例健康体检者作为对照组,两组均进行^(18)F-FDG和^(11)C-CFT PET显像。^(11)CCFT分析:将PD组分为H&Y 1~2(早期)和H&Y 3~5(晚期)2个级别,测得PD组和正常对照组尾状核、前壳核、后壳核的^(11)CCFT标准摄取值,采用独立样本t检验比较PD组和对照组的差异,再将尾状核、前壳核、后壳核分为3组,采用单因素方差分析进行组间对比。^(18)F-FDG分析:结合患者的运动症状进行壳核、丘脑、尾状核及额顶颞枕叶的代谢改变情况分析。结果^(11)C-CFT PET显像:H&Y 1~2(早期)时起病肢体对侧后壳核为低摄取(P<0.05),与正常组比较部分患者起病肢体对侧前壳核、起病肢体同侧后壳核呈低摄取,差异有统计学意义(P<0.05),而起病肢体同侧前壳核、尾状核基本正常,H&Y 3~5(晚期)时起病肢体对侧后壳核摄取更低(P<0.05),起病肢体对侧和同侧后壳核、前壳核均呈不均匀性低摄取,差异有统计学意义(P<0.05);尾状核、前壳核、后壳核三者组间比较,见早、晚期时起病肢体对侧和同侧组间差异均有统计学意义(P<0.05)。^(18)F-FDG PET显像:107例PD患者表现为81.31%壳核代谢增高、54.20%丘脑代谢增高、26.17%尾状核代谢增高,大脑皮层的代谢减低区见89.72%顶叶代谢减低、57.94%额叶代谢减低、68.22颞叶代谢减低、14.02%枕叶代谢减低。结论^(18)F-FDG联合^(11)C-CFT PET双核素影像能够为临床提供客观的数据,辅助诊断、鉴别诊断和评价PD。Objective To study the application of ^(18)F-FDG and ^(11)C-CFT PET imaging in the combined diagnosis,evaluation,and differential diagnosis of Parkinson's disease(PD).Methods A total of 107 patients admitted to our hospital from September 20^(18) to March 2022 who were initially diagnosed as PD according to clinical symptoms and the effectiveness of oral metoba were selected,and 43 healthy subjects were selected as the control group.Both groups underwent ^(18)F-FDG and ^(11)C-CFT PET imaging.^(11)C-CFT analysis:The PD group was divided into two levels:H&Y 1-2(early)and H&Y 3-5(late).The ^(11)C-CFT standard uptake values of the caudate nucleus,anterior putamen nucleus,and posterior putamen nucleus were measured in the PD group and the control group.Independent sample t-test was used to compare the PD group and the control group.The caudate nucleus,anterior putamen nucleus,and posterior putamen nucleus were then divided into three groups,Using oneway ANOVA for inter group comparison;^(18)F-FDG analysis:Analyze the metabolic changes in the putamen,thalamus,caudate nucleus,and frontal parietal temporal occipital lobe based on the patient's motor symptoms.Results ^(11)C-CFT PET imaging:At the early stage of H&Y 1-2,the contralateral posterior putamen of the affected limb showed low metabolism(P<0.05).Compared with the control group,some patients showed low metabolism in the contralateral anterior putamen and ipsilateral posterior putamen of the affected limb,and the results were statistically significant(P<0.05),while the ipsilateral anterior putamen and caudate nuclei of the affected limb were basically normal.In H&Y 3-5(late stage),the metabolism of the posterior putamen on the opposite side of the affected limb was lower(P<0.05).The opposite and ipsilateral posterior putamen and anterior putamen of the affected limb exhibited uneven hypometabolism,and the results were statistically significant(P<0.05);Comparing the caudate nucleus,anterior putamen nucleus,and posterior putamen nucleus,there were differences between

关 键 词：帕金森病 ^(18)F-FDG ^(11)C-CFT 正电子发射计算机断层 诊断 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R817.4[医药卫生—临床医学]