NM23表达对^(18)F-FDG PET/CT在非小细胞肺癌患者放疗计划中的影响  

Effect of NM23 expression on ^(18)F-FDG PET/CT in non-small cell lung cancer radiotherapy schedule

作　　者：夏露花[1] 崇乐 李红玉[3] 夏欢[1] 乔铮[1] 董占飞[1] 赵艳萍[1] 王新华[1] 常诚 XIA Luhua;CHONG Le;Li Hongyu;XIA Huan;QIAO Zheng;DONG Zhanfei;ZHAO Yanping;WANG Xinhua;CHANG Cheng(Department of Nuclear Medicine,Tumor Hospital Affiliated to Xinjiang Medical University,Urumqi 830011,China;Department of Ultrasound Medicine,Tumor Hospital Affiliated to Xinjiang Medical University,Urumqi 830011,China;Department of Breast Medicine,Tumor Hospital Affiliated to Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院核医学科,新疆乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院超声科,新疆乌鲁木齐830011 [3]新疆医科大学附属肿瘤医院乳腺内科,新疆乌鲁木齐830011

出　　处：《分子影像学杂志》2023年第6期978-982,共5页Journal of Molecular Imaging

基　　金：新疆维吾尔自治区科技支疆项目计划(指令性)项目(2022E02050)。

摘　　要：目的分析NM23基因表达情况对非小细胞肺癌的生物学行为及对放疗计划的影响。方法以新疆医科大学附属肿瘤医院107例非小细胞肺癌患者为研究对象,在PET/CT影像下制定放疗方案,勾画一般靶区体积,危及器官受照量,按免疫组化结果分为NM23高表达组(n=43)和低表达组(n=64),比较两组间PET/CT代谢参数最大标准化摄取值、PET/CT图像下勾画的放疗大体靶区体积、危及器官受照量的差异。结果NM23高表达组与低表达组在PET/CT中代谢参数测量的最大标准化摄取值测量方面,高表达组最大标准化摄取值小于低表达组,差异有统计学意义(P<0.05);在NM23低表达组与NM23高表达组制定的放疗计划中,两组在大体靶区体积、危及器官的受照体积方面,NM23高表达组小于低表达组,差异有统计学意义(P<0.05)。结论深入了解非小细胞肺癌患者NM23基因表达情况及其生物学行为,将PET/CT运用于放疗计划的制定中,能够为非小细胞肺癌患者放疗靶区的精准雕刻提供更多的参考信息。Objective To analyze the influence of NM23 gene expression status on the biological behavior of non-small cell lung cancer and on radiotherapy planning.Methods A total of 107 patients with non-small cell lung cancer in the Cancer Hospital of Xinjiang Medical University were taken as the study subjects,and the radiotherapy protocols were formulated under PET/CT images,the general target area volume outlined under PET/CT images,and the amount of critical organs irradiated,which were divided into high NM23 expression group(n=43)and low NM23 expression group(n=64)according to the results of immunohistochemistry,and the differences in the maximal standardized uptake value of metabolic parameters of PET/CT,the PET/CT images,the volume of the radiotherapy macroscopic target area outlined under the images,and the differences in the amount of critical organs irradiated were compared.Results The maximum standardized uptake value of metabolic parameters measured in PET/CT in the NM23 high-expression group was smaller than that of the low-expression group,and the difference was statistically significant(P<0.05).In the radiotherapy plans formulated by the NM23 low-expression group and the NM23 high-expression group,the volume of the macroscopic target area,and the volume of the organs at risk of radiation were smaller than that of the low-expression group in the NM23 high-expression group,and the differences were statistically significant(P<0.05).Conclusion In-depth understanding of NM23 gene expression and its biological behavior in NSCLC patients,and the use of PET/CT in the development of radiotherapy plans can provide more reference information for the precise sculpting of radiotherapy targets in non-small cell lung cancer patients.

关 键 词：PET/CT 放疗计划 最大标准化摄取值 大体靶区体积 危及器官受照体积 

分 类 号：R734.2[医药卫生—肿瘤] R730.44[医药卫生—临床医学]