注射用血塞通联合血栓通胶囊序贯治疗脑梗死恢复期患者的效果  

Effects of Xuesaitong for injection combined with Xueshuantong capsules in sequential treatment of convalescent patients with cerebral infarction

作　　者：郭宗坤 GUO Zongkun(First Ward of Department of Encephalopathy of Zhoukou Hospital of TCM,Zhoukou 466000 Henan,China)

机构地区：[1]周口市中医院脑病一病区,河南周口466000

出　　处：《中国民康医学》2023年第23期38-41,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察注射用血塞通联合血栓通胶囊序贯治疗脑梗死恢复期患者的效果。方法:回顾性分析2020年3月至2022年8月该院收治的108例脑梗死恢复期患者的临床资料,按治疗方法不同将其分为对照组与观察组各54例。对照组采用血栓通胶囊治疗,观察组采用注射用血塞通联合血栓通胶囊序贯治疗。比较两组临床疗效、治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、简易智能精神状态检查量表(MMSE)评分、改良Barthel指数(MBI)评分、凝血功能指标[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)]水平、血清细胞因子[视锥蛋白样蛋白-1(VILIP-1)、心血管活性肽-α(salusin-α)、神经元特异性烯醇化酶(NSE)、血管内皮生长因子(VEGF)]水平和不良反应发生率。结果:观察组治疗总有效率为94.44%(51/54),高于对照组的81.48%(44/54),差异有统计学意义(P<0.05);治疗后,两组NIHSS评分均低于治疗前,且观察组低于对照组,两组MMSE、MBI评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组PT、TT、APTT水平均高于治疗前,且观察组高于对照组,两组FIB水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组VILIP-1、NSE水平均低于治疗前,且观察组低于对照组,两组salusin-α、VEGF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:注射用血塞通联合血栓通胶囊序贯治疗脑梗死恢复期患者可提高治疗总有效率、MMSE评分和MBI评分,改善凝血功能指标和血清细胞因子水平,降低NIHSS评分,其效果优于单纯血栓通胶囊治疗。Objective:To observe effects of Xuesaitong for injection combined with Xueshuantong capsules in sequential treatment of convalescent patients with cerebral infarction.Methods:The clinical data of 108 convalescent patients with cerebral infarction admitted to this hospital from March 2020 to August 2022 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,54 cases in each group.The control group was treated with Xueshuantong capsules,while the observation group was treated with Xuesaitong for injection combined with Xueshuantong capsules sequential therapy.The clinical efficacy,the National Institutes of Health stroke scale(NIHSS)score,the mini-mental state examination(MMSE)score,the modified Barthel index(MBI)score,the coagulation function indexes[prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(FIB)]levels,the serum cytokine indexes[visinin like protein 1(VILIP-1),salusin-α,neuron-specific enolase(NSE),vascular endothelial growth factor(VEGF)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 94.44%(51/54),which was higher than 81.48%(44/54)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS scores of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;the MMSE and MBI scores of the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;and the differences were statistically significant(P<0.05).The levels of PT,TT and APTT in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the levels of FIB in the two groups were lower than those before the treatment,and that in the ob

关 键 词：注射用血塞通 血栓通胶囊 脑梗死 恢复期 神经功能缺损 凝血功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]