肿瘤微环境在乳腺癌发生及转移中的研究进展  

Research progress of tumor microenvironment in the development and metastasis of breast cancer

作　　者：刘俊杰 朱娟英[2] LIU Jun-jie;ZHU Juan-ying(Zhejiang University of Chinese Medicine,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学,310053 [2]嘉兴市妇幼保健院乳腺科,314051

出　　处：《中国实用医药》2023年第23期170-173,共4页China Practical Medicine

摘　　要：乳腺癌(BC)作为最常见的癌症,它的进展及转移能力不仅取决于肿瘤的分型,还取决于它们与肿瘤微环境(TME)中各成分间的相互作用。TME包括癌变细胞和非癌变细胞,包括成纤维细胞、脂肪细胞、内皮细胞和免疫细胞[如巨噬细胞、淋巴细胞、自然杀伤(NK)细胞]、可溶性因子和细胞外基质(ECM)成分,对肿瘤的恶性进展有重要影响。因此临床上BC发生进展时,往往会伴随微环境中某些细胞或因子的改变,目前该综述介绍了微环境对于肿瘤进展和转移的制约,以及肿瘤细胞反过来对于微环境的影响,并讨论了改变TME的可能性。Breast cancer(BC)is the most common cancer,and its ability to progress and metastasize depends not only on the type of tumor,but also on its interaction with the components of the tumor microenvironment(TME).TME includes both cancerous and non-cancerous cells,including fibroblasts,fat cells,endothelial cells and immune cells[such as macrophages,lymphocytes,natural killer(NK)cells],soluble factors and extracellular matrix(ECM)components,which have an important influence on the malignant progression of tumors.Therefore,the clinical progression of BC is often accompanied by changes in some cells or factors in the microenvironment.Now,this review introduces the restriction of the microenvironment on tumor progression and metastasis,as well as the influence of tumor cells on the microenvironment in turn,and discusses the possibility of altering TME.

关 键 词：乳腺癌 肿瘤微环境 免疫细胞 非免疫细胞 

分 类 号：R737.9[医药卫生—肿瘤]