超声辅助乳腺微创旋切术治疗乳腺良性肿瘤的效果及对应激反应的影响  

Effectiveness of Ultrasound-assisted Breast Minimally Invasive Rotational Resection in the Treatment of Benign Breast Tumours and Its Effect on Stress Response

作　　者：郭冀鲁[1] 李远[1] 李芳 韩臻 刘学智[1] 牛俊波[1] GUO Jilu;LI Yuan;LI Fang;HAN Zhen;LIUXuezhi;NIU Junbo(Shouguang People's Hospital,Shandong Province,Shouguang 262700,China)

机构地区：[1]山东省寿光市人民医院,山东寿光262700

出　　处：《中国医学创新》2023年第35期1-5,共5页Medical Innovation of China

摘　　要：目的:探讨超声辅助乳腺微创旋切术治疗乳腺良性肿瘤的效果及对应激反应的影响。方法:选取2018年1月—2022年1月于寿光市人民医院诊治的96例乳腺良性肿瘤患者,使用随机数字表法分为观察组48例及对照组48例,对照组接受开放切除术治疗,观察组接受超声辅助乳腺微创旋切术治疗。对比两组手术相关指标、应激反应指标、致痛物质指标、肿瘤标志物水平及并发症发生率。结果:观察组的手术时间、切口愈合时间、瘢痕长度及住院时间均短于对照组,术中出血量少于对照组,差异均有统计学意义(P<0.05)。术前,两组皮质醇(Cor)、肾上腺素(E)、去甲肾上腺素(NE)、神经肽Y(NPY)、5-羟色胺(5-HT)及前列腺素E_(2)(PGE_(2))水平比较,差异均无统计学意义(P>0.05);术后,两组上述各项指标均较术前升高,但观察组均低于对照组,差异均有统计学意义(P<0.05)。术前,两组癌胚抗原(CEA)及糖类抗原125(CA125)水平比较,差异均无统计学意义(P>0.05);术后,两组上述各项指标均较术前降低,且观察组均低于对照组,差异均有统计学意义(P<0.05)。观察组的并发症发生率为2.08%,低于对照组的14.58%,差异有统计学意义(P<0.05)。结论:超声辅助乳腺微创旋切术治疗乳腺良性肿瘤微创效果显著,可减轻术后应激反应及术后疼痛,调节CEA及CA125水平,减少并发症,安全有效。Objective:To investigate the effectiveness of ultrasound-assisted breast minimally invasive rotational resection in the treatment of benign breast tumors and its effect on stress response.Method:A total of ninety-six patients with benign breast tumors treated in Shouguang People's Hospital from January 2018 to January 2022 were selected,and divided into 48 cases in the observation group and 48 cases in the control group by the random number table method,the control group was treated with open excision,and the observation group was treated with ultrasound-assisted breast minimally invasive rotational resection.Surgical related indicators,stress response indicators,algesic substance indicators,tumor marker level and incidence of complications of two groups were compared.Result:The operative time,incision healing time,scar length and hospital stay in the observation group were shorter than those in the control group,intraoperative bleeding volume was less than that in the control group,the differences were statistically significant(P<0.05).Before surgery,the levels of cortisol(Cor),epinephrine(E),norepinephrine(NE),neuropeptide Y(NPY),5-hydroxytryptamine(5-HT)and prostaglandin E_(2)(PGE_(2))in both groups were compared,the differences were not statistically significant(P>0.05);after surgery,the above indicators in both groups were higher than those before surgery,but those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before surgery,the levels of carcinoembryonic antigen(CEA)and glycoconjugate antigen 125(CA125)in the two groups were compared,the differences were not statistically significant(P>0.05);after surgery,the above indicators in both groups were lower than those before surgery,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of complication rate was 2.08%in the observation group,lower than 14.58%in the control group,the difference was

关 键 词：乳腺良性肿瘤 微创旋切术 应激反应 致痛物质 肿瘤标志物 并发症 

分 类 号：R737.9[医药卫生—肿瘤]