Hypoxic and temporal variation in the endocrine disrupting toxicity of perfluorobutanesulfonate in marine medaka(Oryzias melastigma)  

作　　者：Baili Sun Jing Li Yachen Bai Xiangzhen Zhou Paul K.S.Lam Lianguo Chen 

机构地区：[1]State Key Laboratory of Freshwater Ecology and Biotechnology,Institute of Hydrobiology,Chinese Academy of Sciences,Wuhan 430072,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Office of the President,Hong Kong Metropolitan University,30 Good Shepherd Street,Kowloon,Hong Kong SAR,China

出　　处：《Journal of Environmental Sciences》2024年第2期279-291,共13页环境科学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos.22006159 and 31971236);the Research Grants Council Theme-Based Research Scheme (No.T21-602/16-R);the Natural Science Foundation of Hubei Province,China (No.2021CFA086);the State Key Laboratory of Freshwater Ecology and Biotechnology (No.2022FBZ02)。

摘　　要：Perfluorobutanesulfonate(PFBS)is an emerging pollutant capable of potently disrupting the sex and thyroid endocrine systems of teleosts.However,the hypoxic and temporal variation in PFBS endocrine disrupting toxicity remain largely unknown.In the present study,adult marine medaka were exposed to environmentally realistic concentrations of PFBS(0 and 10μg/L)under normoxia or hypoxia conditions for 7 days,aiming to explore the interactive behavior between PFBS and hypoxia.In addition,PFBS singular exposure was extended till 21days under normoxia to elucidate the time-course progression in PFBS toxicity.The results showed that hypoxia inhibited the growth and caused the suspension of egg spawn regardless of PFBS exposure.With regard to the sex endocrine system,7-day PFBS exposure led to an acute stimulation of transcriptional profiles in females,which,subsequently,recovered after the 21-day exposure.The potency of hypoxia to disturb the sex hormones was much stronger than PFBS.A remarkable increase in estradiol concentration was noted in medaka blood after hypoxia exposure.Changes in sex endocrinology of coexposed fish were largely determined by hypoxia,which drove the formation of an estrogenic environment.PFBS further enhanced the endocrine disrupting effects of hypoxia.However,the hepatic synthesis of vitellogenin and choriogenin,two commonly used sensitive biomarkers of estrogenic activity,failed to initiate in response to the estrogen stimulus.Compared to sex endocrine system,disturbances in thyroidal axis by PFBS or hypoxia were relatively mild.Overall,the present findings will advance our toxicological understanding about PFBS pollutant under the interference of hypoxia.

关 键 词：Perfluorobutanesulfonate(PFBS) Aquatic hypoxia Temporal toxicity Combined exposure Endocrine disruption Marine medaka 

分 类 号：X171.5[环境科学与工程—环境科学]