子宫内膜癌组织COX-2、p53、E-cadherin蛋白表达及与临床病理参数和预后关系  

Protein expressions of the cyclooxygenase 2,p53,and epithelial cadherin in the endometrial cancer tissues of women and their correlations with the clinicopathological parameters and prognosis

作　　者：李俊国 臧鲖临 LI Junguo;ZANG Tonglin(Linquan County People's Hospital,Fuyang,Anhui Province,236400)

机构地区：[1]安徽省临泉县人民医院,236400

出　　处：《中国计划生育学杂志》2023年第12期3005-3010,共6页Chinese Journal of Family Planning

摘　　要：目的:探究子宫内膜癌组织环氧合酶-2(COX-2)、p53、上皮细胞钙粘蛋白(E-cadherin蛋白)表达及与患者临床病理特征、预后关系。方法:选取2014年1月-2017年12月104例子宫内膜癌患者为恶性组,同期46例子宫内膜不典型增生(不典型增生组)、34例正常增殖期子宫内膜(正常组)进行对照,采用免疫组织化学法检测各组织COX-2、p53、E-cadherin蛋白表达,并分析其与子宫内膜癌患者临床病理特征关系;采用Spearman秩相关分析法探究COX-2、p53、E-cadherin蛋白表达相关性;随访5年,采用Kaplan-Meier法分析COX-2、p53、E-cadherin蛋白表达与患者生存预后关系。结果:恶性组COX-2(73.1%)、p53(58.7%)阳性表达率均高于不典型增生组(15.2%、6.5%)和正常组(8.8%、0),E-cadherin阳性表达率(38.5%)低于不典型增生组(89.1%)和正常组(97.1%)(均P<0.05)。恶性组COX-2表达与肌层浸润、淋巴结转移、FIGO分期有关,p53与分化程度、淋巴结转移、FIGO分期有关,E-cadherin与分化程度、肌层浸润、淋巴结转移、FIGO分期有关(均P<0.05)。Spearman秩相关分析显示,恶性组COX-2与p53表达呈正相关,与E-cadherin呈负相关,p53与E-cadherin表达呈负相关(均P<0.05)。随访5年,恶性组32例(30.8%)死亡,死亡组COX-2、p53阳性表达率高于存活组,E-cadherin阳性表达率低于存活组(均P<0.05)。Kaplan-Meier生存分析显示,COX-2、p53阳性表达组生存期均低于相应阴性表达组,E-cadherin阴性表达组生存期低于阳性表达组(均P<0.05)。结论:子宫内膜癌组织COX-2、p53蛋白异常高表达,E-cadherin蛋白异常低表达,且与患者临床病理参数、预后有关,可作为子宫内膜癌预后评估参考指标。Objective:To explore correlation between the protein expressions of the cyclooxygenase-2(COX-2),p53,and epithelial cadherin(E cadherin)in the endometrial cancer tissues of women and their clinicopathological parameters and prognosis.Methods:104women with endometrial cancer were selected in group A,46women with endometrial atypical hyperplasia in group B,and 34women with normal proliferative endometrium were selected in group C from January 2014to December 2017.The protein expressions of COX 2,p53,and E cadherin in the endometrial cancer tissues or the endometrial tissues of the women in the three groups were detected by immunohistochemical method.The correlation between the protein expressions of COX 2,p53,and E cadherin of the women with endometrial cancer and their clinicopathological characteristics was analyzed.Spearman rank correlation analysis was used to explore the correlation among the protein expressions of COX 2,p53,and E cadherin of the women.The women in group A were followed up for 5years,and the correlation between the protein expressions of COX 2,p53,and E cadherin of the women and their survival prognosis was analyzed by Kaplan Meier method.Results:The positive expression rates of COX 2 protein(73.1%)and p53protein(58.7%)of the women in group A were significantly higher than those(15.2%and 6.5%)of the women in group B and those(8.8%and 0)of the women in group C.The positive expression rate of E cadherin protein(38.5%)of the women in group A was significantly lower than that(89.1%)of the women in group B and that(97.1%)of the women in group C(all P<0.05).The COX 2protein expression of the women in group A was associated with their muscular infiltration,lymph node metastasis,and FIGO staging.The p53protein expression of the women in group A was associated with their degree of differentiation,lymph node metastasis,and FIGO staging.The E cadherin protein expression of the women in group A was associated with their degree of differentiation,muscular infiltration,lymph node metastasis,and FIGO staging(

关 键 词：子宫内膜癌 环氧合酶-2 p53蛋白 E-CADHERIN蛋白 临床病理特征 预后 

分 类 号：R737.33[医药卫生—肿瘤]