含铂方案辅助化疗对老年晚期非小细胞肺癌患者生存的影响  

Effect of platinum-containing regimen combined with chemotherapy on the survival of elderly patients with advanced non-small cell lung cancer

作　　者：王雪星 何媛 楚杰 王羽丰[2] Xue-Xing WANG;Yuan HE;Jie CHU;Yu-Feng WANG(Department of Oncology,Anning First People's Hospital,Kunming University of Science and Technology,Kunming 650300,China;Department of Cadre Healthcare,The Third Affiliated Hospital of Kunming Medical University,Kunming 650000,China;Department of Oncology,Ziyang Hospital,West China Hospital,Sichuan University,Ziyang 641399,Sichuan Province,China)

机构地区：[1]昆明理工大学附属安宁市第一人民医院肿瘤科,昆明650300 [2]昆明医科大学第三附属医院干部医疗科,昆明650000 [3]四川大学华西医院资阳医院肿瘤科,四川资阳641399

出　　处：《数理医药学杂志》2023年第12期899-905,共7页Journal of Mathematical Medicine

摘　　要：目的探讨含铂方案辅助化疗对70岁及以上晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者预后的影响。方法采取回顾性队列研究,选取2016年6月至2019年6月安宁市第一人民医院收治的年龄≥70岁的晚期NSCLC患者为研究对象,根据治疗方式将患者分为化疗组与最佳支持治疗(best supportive care,BSC)组,比较两组患者的生存率,分析影响老年晚期NSCLC患者生存和预后的相关因素。结果共纳入305例患者,化疗组与BSC组患者生存中位数分别为11个月、2个月;Kaplan-Meier生存分析结果显示,化疗组患者的6个月(76.5%vs.17.9%,P<0.001)、1年(51.9%vs.12.1%,P<0.001)、3年(23.5%vs.0%,P<0.001)生存率均高于BSC组患者。而<75岁和≥75岁两个年龄组患者中位生存时间分别为13个月、11个月,3年生存率分别为7.6%、4.5%。不同年龄组患者3年总生存期无统计学差异(P=0.491)。Cox多因素回归分析显示,合并症与治疗方式是影响70岁及以上晚期NSCLC患者预后的独立影响因素(P<0.05)。结论接受含铂方案辅助化疗的老年晚期NSCLC患者预后显著优于BSC患者,合并症、治疗方式是影响老年晚期NSCLC患者不良预后的独立危险因素。Objective To investigate the effect of platinum-containing regimen combined with chemotherapy on the prognosis of patients aged over 70 years with advanced non-small cell lung cancer(NSCLC).Methods Through a retrospective cohort study,patients with NSCLC aged≥70 years who were admitted to Anning First People's Hospital from June 2016 to June 2019 were selected as the study subjects,and the patients were divided into chemotherapy group and best supportive care(BSC)group according to the treatment methods,the survival rates of the two groups were compared,and the relevant factors affecting the survival and prognosis of elderly NSCLC patients were analyzed.Results A total of 305 patients were included.The medians survival of patients in chemotherapy group and BSC group were 11 months and 2 months,respectively.Kaplan-Meier survival analysis showed that the 6-month(76.5%vs.17.9%,P<0.001),1-year(51.9%vs.12.1%,P<0.001)and 3-year(23.5%vs.0%,P<0.001)survival rates in the chemotherapy group were significantly higher than those in the BSC group.The 3-year survival rates of patients aged<75 years and≥75 years were 7.6%and 4.5%,respectively.There was no statistically significant difference in the total 3-year survival period between two groups(P=0.491).Cox multivariate analysis showed that complications and treatment methods were independent factors affecting the prognosis of patients aged over 70 years with advanced NSCLC(P<0.05).Conclusion The prognosis of elderly NSCLC patients receiving platinum-containing regimen combined with chemotherapy is significantly better than that of patients receiving BSC,and the treatment regimens and complications are independent risk factors affecting the poor prognosis of elderly NSCLC patients.

关 键 词：非小细胞肺癌 回顾性队列研究 化疗 老年 生存分析 

分 类 号：R734.2[医药卫生—肿瘤]