NuMA核型阳性患者的临床特征分析  

Clinical characteristics of patients with positive NuMA karyotype

作　　者：申甫英 魏彬[2] 罗敏 SHEN Fuying;WEI Bin;LUO Min(Longquanyi District First People′s Hospital Sichuan University West China Hospital Longquan Hospital,Chengdu,Sichuan 610100,China;Experimental Medicine Department,Sichuan University West China Hospital,Chengdu,Sichuan 610044,China)

机构地区：[1]成都市龙泉驿区第一人民医院四川大学华西医院龙泉医院,四川成都610100 [2]四川大学华西医院实验医学科,四川成都610044

出　　处：《国际检验医学杂志》2023年第S02期113-117,共5页International Journal of Laboratory Medicine

摘　　要：目的分析抗有丝分裂体(NuMA)核型阳性患者的临床特征,为医生对该类患者临床诊治提供参考依据。方法纳入2019年5月至2020年12月于四川大学华西医院行抗核抗体(ANA)检测的患者为研究对象,收集并分析其中NuMA型阳性患者的临床诊疗及实验室检测特点。结果114215例筛查ANA的患者中,ANA阴性75475例(66.08%),ANA阳性38740例(33.92%),滴度1∶100的NuMA型174例(54.55%),其中NuMA1有166例(52.04%),NuMA2有8例(2.51%);滴度大于等于1∶320的NuMA型145例(45.45%),其中NuMA1有133例(41.69%),NuMA2有12例(3.76%)NuMA阳性率为0.28%(319/114215)。NuMA核型阳性可出现在全身各系统的疾病中,其中(NuMA≥320)排名前三位的为自身免疫性疾病43.45%(63/145)、呼吸系统疾病15.17%(22/145)、肾脏病5.51%(8/145)。结论NuMA型是一种少见的荧光核型,流行率低,疾病分布范围广,主要分布在自身免疫性疾病,可作为自身免疫性疾病的潜在提示指标;也可为其他疾病提供参考依据。Objective To analyze the clinical characteristics of patients with positive NuMA karyotype,and to provide reference for clinical diagnosis and treatment of these patients.Methods Patients who underwent antinucleic antibody(ANA)test in West China Hospital of Sichuan University from May 2019 to December 2020 were included in the study,and the characteristics of clinical diagnosis,treatment and laboratory test of NuMA positive patients were collected and analyzed.Results Among the 114,215 patients screened for ANA,75,475(66.08%)were ANA negative and 38,740(33.92%)were ANA positive,with titer 1∶174 people(54.55%)were NuMA type 100,including 166 people(52.04%)for NuMA1 and 8 people(2.51%)for NuMA2.The positive rate of NuMA was 0.28%(319/114215)in 145 patients(45.45%)with titer greater than or equal to 1∶320,including 133 patients(41.69%)in NuMA1 and 12 patients(3.76%)in NuMA2.Positive NuMA karyotype can occur in systemic diseases,among which the top three NuMA≥320 were autoimmune diseases 43.45%(63/145),respiratory diseases 15.17%(22/145)and kidney diseases 5.51%(8/145).Conclusion NuMA type is a rare fluorescent karyotype with low prevalence and a wide range of disease distribution,mainly distributed in autoimmune diseases,which can be used as a potential indicator of autoimmune diseases.It can also provide reference for other diseases.

关 键 词：自身抗体 抗有丝分裂体 流行率 实验室检查 

分 类 号：R73[医药卫生—肿瘤]