序贯疗法联合益生菌对幽门螺杆菌疗效的meta分析  

Sequential therapy combined with probiotics for helicobacter pylori:a meta-analysis

作　　者：谢嘉欣 刁德昌[2] 魏琳[3] 刘杨晨[3] 谭萍[2] 尤久红 隆丽芳 谢湘萁 朱鑫鑫 林美珍[3] Xie Jiaxin;Diao Dechang;Wei Lin;Liu Yangchen;Tan Ping;You Jiuhong;Long Lifang;Xie Xiangqi;Zhu Xinxin;Lin Meizhen(Second Clinical Medical College,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China;Gastrointestinal Tumor Center,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120,China;Department of Nursing,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120,China;College of Nursing,Hunan University of Traditional Chinese Medicine,Changsha 410208,China)

机构地区：[1]广州中医药大学第二临床医学院,广州510405 [2]广东省中医院胃肠肿瘤中心,广州510120 [3]广东省中医院护理部,广州510120 [4]湖南中医药大学护理学院,长沙410208

出　　处：《国际医药卫生导报》2023年第24期3590-3598,共9页International Medicine and Health Guidance News

基　　金：广州市科技计划项目(202002030436、202102010240);广东省中医院中医药科学技术研究专项(YN2022HL.01)。

摘　　要：目的系统评价序贯疗法联合益生菌治疗幽门螺杆菌(Helicobacter pylori,Hp)感染的疗效和安全性。方法检索从建库至2022年6月20日采用序贯疗法联合益生菌治疗Hp感染的随机对照试验研究,根据纳排标准筛选文献,用改良版Jadad量表进行偏倚风险的评价,采用RevMan 5.3软件进行统计与分析。结果共纳入22项随机对照试验研究,总计3158例患者。Meta分析结果显示:序贯疗法联合益生菌治疗Hp感染总转阴率(OR=3.99,95%CI 3.10~5.14,P<0.001)、有效率(OR=4.98,95%CI 3.57~6.94,P<0.001)、复发率(OR=0.20,95%CI 0.07~0.56,P=0.002)、症状积分(OR=-1.41,95%CI-1.51~-1.31,P<0.001)、不良反应率(OR=0.28,95%CI 0.21~0.36,P<0.001)均优于单纯序贯疗法。结论与单纯序贯疗法治疗Hp感染相比,序贯疗法联合益生菌治疗Hp感染的转阴率和有效率更高,症状积分、复发率、不良反应发生率更低。Objective To systematically evaluate the efficacy and safety of sequential therapy combined with probiotics in the treatment of Helicobacter pylori(Hp)infection.Methods The randomized controlled trials of sequential therapy combined with probiotics in the treatment of Hp infection were retrieved from the establishment to June 20,2022.The literatures were screened according to the inclusion criteria.The modified Jadad scale was used to evaluate the bias risk.The RevMan5.3 software was used for the statistics and analysis.Results A total of 22 randomized controlled trials involving 3158 patients were included.Meta-analysis results showed that the total negative conversion rate(OR=3.99,95%CI 3.10-5.14,P<0.001),effective rate(OR=4.98,95%CI 3.57-6.94,P<0.001),recurrence rate(OR=0.20,95%CI 0.07-0.56,P=0.002),symptom score(OR=−1.41,95%CI−1.51-−1.31,P<0.001),and incidence of adverse reactions(OR=0.28,95%CI 0.21-0.36,P<0.001)of sequential therapy combined with probiotics in the treatment of Hp infection were better than those of the control group.Conclusion The negative conversion rate and effective rate of sequential therapy combined with probiotics in the treatment of Hp infection are higher than those of the simple sequential therapy,and the symptom score,recurrence rate,and incidence of adverse reactions are lower.

关 键 词：序贯疗法 益生菌 幽门螺杆菌感染 不良反应 META分析 

分 类 号：R573[医药卫生—消化系统]