麝香化瘀醒脑颗粒治疗中小量脑出血的临床观察  

Clinical Study on the Treatment of Small and Moderate Cerebral Hemorrhage with Shexiang Huayu Xingnao Granules

作　　者：杨云芳 白雪 杨思进 唐红梅 胡珊珊 黄江 Yang Yunfang;Bai Xue;Yang Sijin;Tang Hongmei;Hu Shanshan;Huang Jiang(The Affiliat-ed Traditional Chinese Medicine Hospital of Southwest Medical University,Sichaun,Luzhou 646000,China)

机构地区：[1]西南医科大学附属中医医院,四川泸州646000

出　　处：《中国中医急症》2023年第12期2155-2158,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：四川省科技厅项目(2020YJ0437);西南医科大学-西南医科大学附属中医医院联合项目(2020XYLH-025)。

摘　　要：目的观察麝香化瘀醒脑颗粒对中小量脑出血患者的临床疗效并探讨其作用机制,为研制治疗中小量脑出血的有效中药复方制剂提供循证证据。方法60例患者随机分为对照组与治疗组各30例。对照组予常规治疗,治疗组在此基础上口服麝香化瘀醒脑颗粒,疗程均为7 d。观察两组患者治疗前后的中医证候疗效、无创脑水肿监测指数、中医症状评分、美国国立卫生研究院卒中量表(NIHSS)评分,平均住院时间及并发症的发生情况。结果两组治疗后中医症状评分、NIHSS评分和无创脑水肿监测指数均较治疗前下降,且治疗组中医症状评分、NIHSS评分和无创脑水肿监测指数下降较对照组更明显(均P<0.05)。治疗组总有效率为93.33%,高于对照组的73.33%(P<0.05)。治疗组并发症发生率为10.00%,低于对照组的43.33%,平均住院时间短于对照组(均P<0.05)。观察期间,两组均未发生药物相关不良反应。结论麝香化瘀醒脑颗粒可明显减轻中小量脑出血患者脑水肿,改善患者临床症状和神经功能缺损评分,缩短平均住院时间。Objective:To observe the effect of Shexiang Huayu Xingnao Granules on the clinical efficacy of pa⁃tients with small and moderate amount of cerebral hemorrhage,and to provide reliable evidence for the develop⁃ment of effective Chinese herbal compound preparations for the treatment of moderate and small amount of cere⁃bral hemorrhage.Methods:60 patients with small and moderate cerebral hemorrhage were randomly divided into control group and treatment group,with 30 patients in each group.The control group was given routine western medicine treatment,and the treatment group was given Shexiang Huayu Xingnao Granules orally on this basis.Both groups were treated for 1 course of treatment of 7 days.The changes of non-invasive brain edema monitoring index,TCM symptom score,NIHSS score,average hospitalization days and complications of the two groups were ob⁃served before and after treatment.Results:The non-invasive brain edema monitoring index,TCM symptom score and NIHSS score in the treatment group were significantly improved compared with those before treatment;com⁃pared with the control group,the complications were reduced and the average hospital stay was shortened,and the difference was statistically significant(all P<0.05).The total effective rate of the treatment group(93.33%)was higher than that of the control group(73.33%)(P<0.05).The incidence of complication in the treatment group was 10.00%,lower than 43.33%in the control group(P<0.05).The average length of hospital stay in the treat⁃ment group was shorter than that in the control group.Conclusion:Shexiang Huayu Xingnao Granules can signifi⁃cantly reduce brain edema in patients with small and moderate cerebral hemorrhage,improve clinical symptoms and neurological deficit scores,and shorten the average hospital stay.

关 键 词：中小量脑出血 “脑玄府”理论 麝香化瘀醒脑颗粒 

分 类 号：R743.34[医药卫生—神经病学与精神病学]