认知功能康复训练联合药物治疗血管性痴呆患者的疗效观察  

Observation on the Effect of Cognitive Rehabilitation Training Combined with Drugs on Vascular Dementia Patients

作　　者：朱凯凤 陈雅惠 洪志评 邓婷 ZHU Kaifeng;CHEN Yahui;HONG Zhiping;DENG Ting(Department of Rehabilitation Medicine,Xiamen Fifth Hospital,Xiamen 361101,China)

机构地区：[1]厦门市第五医院康复医学科,福建厦门361101

出　　处：《中国医药指南》2023年第36期69-71,共3页Guide of China Medicine

摘　　要：目的探究艾地苯醌联合认知功能康复训练治疗血管性痴呆患者临床治疗价值。方法选我院2020年1月至2022年12月期间80例血管性痴呆患者为研究对象,以随机数字表法分为对照组、观察组,各40例,分别接受艾地苯醌治疗、艾地苯醌+认知功能康复训练治疗,比较两组治疗前后智力水平(MMSE)、日常生活能力(ADL)、氧化应激因子[谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、超氧化物歧化酶(SOD)]水平。结果治疗前两组MMSE、ADL水平相近(P>0.05);治疗后观察组MMSE、ADL评分较对照组高(P<0.05)。治疗前两组GSH-Px、MDA、SOD水平相近(P>0.05);治疗后观察组GSH-Px、SOD水平较对照组高,MDA水平较对照组低(P<0.05)。结论对血管性痴呆患者应用艾地苯醌+认知功能康复治疗,可改善患者认知功能及生活能力,改善其氧化应激反应水平,效果理想。Objective To explore the clinical value of the combination of idebenone and cognitive rehabilitation training in the treatment of vascular dementia.Methods 80 patients with vascular dementia in our hospital from January 2020 to December 2022 were selected as the study subjects.Divided into control group and observation group by random number table method,40 cases in each group.They were treated with idebenone and idebenone+cognitive function rehabilitation training respectively.The intelligence level(MMSE),ability of daily living(ADL)before and after treatment were compared between the two groups Levels of oxidative stress factors[glutathione peroxidase(GSH-Px),malondialdehyde(MDA),superoxide dismutase(SOD)].Results Before treatment,the levels of MMSE and ADL in the two groups were similar(P>0.05);After treatment,the scores of MMSE and ADL in the observation group were higher than those in the control group(P<0.05);Before treatment,the levels of GSH-Px,MDA and SOD in the two groups were similar(P>0.05);After treatment,the level of GSH-Px and SOD in the observation group was higher than that in the control group,and the level of MDA was lower than that in the control group(P<0.05).Conclusions The application of idebenone+cognitive rehabilitation therapy to vascular dementia patients can improve the cognitive function and living ability of patients,and improve the level of oxidative stress reaction,with ideal effect.

关 键 词：血管性痴呆 艾地苯醌 认知功能康复训练 

分 类 号：R743[医药卫生—神经病学与精神病学]