高帧频超声造影与增强磁共振对不同直径原发性高分化肝细胞癌的诊断价值  

Diagnostic value of high-frequency ultrasonography and enhanced magnetic resonance for primary hyperdifferentiated hepatocellular carcinoma of different diameters

作　　者：吴凤芸[1] 滕鑫[1] 刘连娟[1] Fengyun Wu;Xin Teng;Lianjuan Liu(Department of Ultrasound,Qingdao Hospital,Rehabilitation University(Qingdao Municipal Hospital),Qingdao 266000,China)

机构地区：[1]康复大学青岛医院(青岛市市立医院)超声科,山东省266000

出　　处：《中华消化病与影像杂志（电子版）》2023年第6期404-408,共5页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的探究高帧频超声造影(H-CEUS)与增强磁共振(CE-MRI)对不同直径原发性高分化肝细胞癌的诊断价值。方法回顾性纳入2020年1月1日至2023年1月1日在康复大学青岛医院经病理诊断为原发性高分化肝细胞癌的128例患者,其中9例患者不符合纳入标准,5例患者资料不全,最终本研究纳入114例原发性高分化肝细胞癌患者作为研究对象。以病理诊断为金标准,所有患者均行H-CEUS和CE-MRI检查,对比两种检查方法的诊断效能和检查结果的一致性以及对不同大小病灶的诊断效能和检查结果的一致性。结果CE-MRI的诊断准确性(98.24%)、灵敏度(98.18%)和特异度(100%)显著高于H-CEUS,差异均有统计学意义(P<0.05)。相比H-CEUS,CEMRI检查结果与病理金标准检查结果的一致性更强(Kappa=0.804),差异有统计学意义(P<0.05)。在直径≥5 mm的原发性高分化肝细胞癌病灶中,H-CEUS和CE-MRI诊断的准确性、灵敏度、特异度,差异无统计学意义(P>0.05),两者检查结果的一致性较强(Kappa=0.743);在直径<5 mm的原发性高分化肝细胞癌病灶中,CE-MRI诊断的准确性、灵敏度、特异度均显著高于H-CEUS(P<0.05),两者检查结果的一致性一般(Kappa=0.692)。结论H-CEUS和CE-MRI对不同直径的原发性高分化肝细胞癌病灶均有一定的诊断价值,但CE-MRI对直径<5 mm的病灶具有更好的诊断效能,与病理诊断一致性更高。Objective To explore the diagnostic value of high-frequency contrast-enhanced ultrasonography(H-CEUS)and contrast enhanced magnetic resonance imaging(CE-MRI)in primary highly differentiated hepatocellular carcinoma of different diameters.Methods A total of 128 patients pathologically diagnosed with primary hyperdifferentiated hepatocellular carcinoma in Qingdao Hospital of Rehabilitation University from January 1,2020 to January 1,2023 were retrospectively included,including 9 patients who did not meet the inclusion criteria and 5 patients had incomplete data.Finally,114 patients with primary hyperdifferentiated hepatocellular carcinoma were included as research objects.With pathological results as the gold standard,all patients were examined by H-CEUS and CE-MRI,and the diagnostic efficacy and consistency of the two detection methods were compared,as well as the diagnostic efficacy and consistency of the examination results for lesions of different sizes.Results The diagnostic accuracy(98.24%),sensitivity(98.18%)and specificity(100%)of CE-MRI were significantly higher than those of H-CEUS,with statistically significant differences(P<0.05).Compared with H-CEUS,the results of CE-MRI were more consistent with those of pathological gold standard(Kappa=0.804),with statistically significant differences(P<0.05).In primary hyperdifferentiated hepatocellular carcinomas with a diameter≥5 mm,there were no statistically significant differences in the diagnostic accuracy,sensitivity and specificity between H-CEUS and CE-MRI(P>0.05),and there was strong consistency between the two detection results(Kappa=0.743).In the primary hyperdifferentiated hepatocellular carcinomas<5 mm in diameter,the diagnostic accuracy,sensitivity and specificity of CE-MRI were significantly higher than those of H-CEUS(P<0.05),and the results of the two tests were generally consistent(Kappa=0.692).Conclusion Both H-CEUS and CE-MRI are valuable in the diagnosis of primary hyperdifferentiated hepatocellular carcinomas of different diameters.However,C

关 键 词：原发性高分化肝细胞癌 高帧频超声造影 增强磁共振 诊断 

分 类 号：R735.7[医药卫生—肿瘤] R445[医药卫生—临床医学]