线粒体自噬在抑郁症发病机制及治疗中作用的研究进展  

Research Progress on the Role of Mitophagy in the Pathogenesis and Treatment of Depression

作　　者：刘嘉诚 赵娜[1] 康传依 王晓红[1] 胡建[1] LIU Jiacheng;ZHAO Na;KANG Chuanyi;WANG Xiaohong;HU Jian(Mental Health Center,The First Affiliated Hospital of Harbin Medical University,Harbin 150000,China)

机构地区：[1]哈尔滨医科大学附属第一医院精神卫生中心,哈尔滨150000

出　　处：《神经损伤与功能重建》2023年第12期789-792,共4页Neural Injury and Functional Reconstruction

基　　金：国家重点研发计划课题(No.2016YFC1307204)。

摘　　要：抑郁症是一种病因未明的精神障碍,具有高患病率、高复发率和治疗难度大的特点。线粒体作为细胞的“能量工厂”是神经元生存和活动的重要细胞器。线粒体自噬作为一种进化上高度保守的溶酶体降解途径,可以特异性地清除细胞中受损的线粒体。近年研究表明线粒体自噬受损可能是抑郁症的一种促成因素。本文基于线粒体自噬进程对线粒体自噬在抑郁症发病机制及治疗中作用作一综述,并讨论了目前研究的局限性,以期为抑郁症的诊断及治疗提供新思路。Depression is a mental disorder of unknown etiology,characterized by high prevalence,high relapse rate,and difficulty in treatment.Mitochondria,as the"energy factory"of cells,are essential organelles for the survival and activity of neurons.Mitophagy,an evolutionarily highly conserved lysosomal degradation pathway,can precisely remove damaged mitochondria in cells.Recent studies have shown that impaired mitophagy may contribute to depression.Based on the process of mitophagy,this article reviews the role of mitophagy in the pathogenesis and treatment of depression and discusses the limitations of current research in order to provide new ideas for the diagnosis and treatment of depression.

关 键 词：线粒体自噬 抑郁症 发病机制 治疗 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学] R749