肠道菌群代谢物对甲酚和对乙酚与孤独症谱系障碍的相关性及其潜在致病机制  

Relevance and Potential Pathogenetic Mechanisms of Gut Microbiota-Derived Metabolites p-Cresol and 4-Ethylphenol in Autism Spectrum Disorder

作　　者：张学超 窦婧菲 王娟[3] ZHANG Xue-Chao;DOU Jing-Fei;WANG Juan(Department of Microbiology and Infectious Disease Center,School of Basic Medical Sciences,Peking University,Beijing 100191,China;High School Affiliated to Shanghai Jiaotong University,Shanghai 200439,China;Department of Biomedical Informatics,School of Basic Medical Sciences,Peking University,Beijing 100191,China)

机构地区：[1]北京大学基础医学院病原生物学系,北京100191 [2]上海交通大学附属中学,上海200439 [3]北京大学基础医学院医学生物信息学系,北京100191

出　　处：《生理科学进展》2023年第6期517-525,共9页Progress in Physiological Sciences

基　　金：国家自然科学基金(82171169)资助课题。

摘　　要：孤独症谱系障碍(autism spectrum disorder,ASD)是一类患病率高且病因复杂的神经发育障碍性疾病,患者主要特征为社会交往与交流障碍并表现出兴趣狭窄与重复刻板行为。临床证据表明肠道菌群失衡普遍存在于ASD患者群体中并参与ASD的发病,但其中机制还有待明确。近期研究发现肠道菌群可能间接通过其代谢产物影响ASD的发展。本综述将重点阐述两种肠道菌群代谢物——对甲酚和对乙酚与ASD之间的相关性及其潜在致病机制,以期发掘肠道菌群在ASD发病过程中的潜在作用与机理,并为ASD的诊断与治疗提供新思路。Autism spectrum disorder(ASD)is a highly prevalent neurodevelopmental disorder with a complex etiology,characterized by impairments in social interactions and communications,restricted interests,as well as repetitive and stereotypic behaviors.Clinical evidence has indicated that the gut microbiota in ASD patients varies from that in healthy individuals and participates in the pathogenesis of ASD.However,the underlying mechanism remains unclear.Recent studies have identified that the gut microbiota may indirectly contribute to the development of ASD through its metabolites.This review summarizes the relevance of two metabolites of gut microbiota,p-cresol and 4-ethylphenol,to ASD,along with their underlying pathogenic mechanisms.The aim is to explore the potential role of gut microbiota in ASD pathogenesis,providing new insights into the diagnosis and treatment of ASD.

关 键 词：孤独症谱系障碍 肠道菌群 对甲酚 对乙酚 菌肠脑轴 

分 类 号：R363[医药卫生—病理学] R378[医药卫生—基础医学] R741