Exploring the interplay of lncRNA,senescence and urinary tumors:opportunities and challenges  

作　　者：De-Chao Feng Rui-Cheng Wu Zhou-Ting Tuo Jie Wang Xing Ye Deng-Xiong Li 

机构地区：[1]Department of Urology,Institute of Urology,West China Hospital,Sichuan University,Chengdu 610041,China [2]Department of Rehabilitation,the Affiliated Hospital of Southwest Medical University,Luzhou 646000,China [3]Department of Urology,the Second Affiliated Hospital of Anhui Medical University,Hefei 230601,China [4]Samuel Oschin Comprehensive Cancer Institute,Department of Medicine,Department of Biomedical Sciences,Cedars-Sinai Medical Center,Los Angeles,CA 90048,USA

出　　处：《Aging Communications》2023年第4期1-2,共2页衰老通讯

摘　　要：Introduction About 72%of human genome is transcribed to non-coding RNAs,which have captivated researchers a lot for shedding light on their pivotal roles in regulating the initiation and progression of various diseases,including cancers[1].Among these,long non-coding RNAs(lncRNAs)have emerged as key players in the complex landscape of gene regulation.LncRNAs perform a variety of roles,including scaffolding to encourage the interaction of related proteins,decoys to thwart transcriptional factors from the target gene’s promoter,sponges of linked miRNA to prevent target gene destruction,and guide molecules to recruit components for chromatin remodeling[1].Many cancers are closely related to age[2-5]and such patients are expected be increased gradually as almost 20%of the world’s population will be 65 or older by 2030[6]and those over the age of 65 have an 11-fold higher incidence of cancer than people under that age[7].As one of the typical hallmarks of aging[8],cellular senescence is Cellular senescence is induced by stressful insults and certain physiological processes and is characterized by a prolonged and essentially irreversible cell-cycle arrest with secretory features,macromolecular damage,and altered metabolism[9].Here,we aim to provide insights of the intersection between lncRNAs,cellular senescence,and urinary tumors,unraveling the potential implications and therapeutic avenues within this multifaceted network.

关 键 词：URINARY METABOLISM IRREVERSIBLE 

分 类 号：R73[医药卫生—肿瘤]