Proper beverages may reduce the risk of Alzheimer’s disease  

作　　者：Lian-Yi Hu Shi-Jin Cheng Jia-Rong Shi Yu-Hui Wang Xin-Ju Li 

机构地区：[1]College of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [2]College of Integrated Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China

出　　处：《Aging Communications》2023年第4期3-6,共4页衰老通讯

摘　　要：Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, characterized by a progressive decline in cognitive ability. Around 50 million people worldwide are reportedly affected, with annual losses estimated at about $1 trillion [1]. Nevertheless, there remains unknown about the exact pathological mechanisms of AD and currently available treatments have a lack of efficacy. Thus, experts have reached a consensus that interventions in the preclinical stage of AD should be prioritized [2], especially when the amount of patients is set to reach 78 million by the end of this decade [3]. Recently, the proposition “integrating food and nutrition into healthcare” has been promoted [4]. Prevention from dietary eating and drinking may be an effective and age-friendly method. Nowadays, many beverages have been proven to offer great preventative benefits to AD like coffee, soy milk, tea, and wine. Coffee, consumed by tens of thousands of people every day, has been proven in several epidemiological studies to have a protective effect against AD [5-7]. A study including 411 individuals shows that significant negative correlation between stratified lifetime coffee intake and β-amyloid positivity [8]. In other words, higher coffee intake (≥ 2 cups/day) is associated with lower risk of AD. However, a Mendelian randomization (MR) analysis came to the opposite conclusion, with an additional 1 cup of coffee per day being associated with a 1.16-fold increased risk of developing AD [9]. In meta-analyses of cohort studies, it was proposed that there was a non-linear “U-shaped” link between coffee consumption and AD, with 3-4 cups per day being optimal [10]. In addition to the possibility that different conclusions are due to inconsistent estimations of coffee intake and populations in these studies, research recently proposed a hypothesis that the cytochrome P450 1A2 played an essential role in the metabolism of coffee in the human body [11]. Rs762551 is its most representative and commonly studied si

关 键 词：METABOLISM protective integrating 

分 类 号：R74[医药卫生—神经病学与精神病学]