Activation of Nrf2 alleviates Parkinson’s disease-like pathology:a new strategy targeting the C/EBPβ/α-Syn pathway  

作　　者：Ze-Fang Lin Wei Yao 

机构地区：[1]Department of Physiology,School of Medicine,Jinan University,Guangzhou 510632,China [2]Guangzhou Key Laboratory of Formula-pattern Research Center,School of Traditional Chinese Medicine,Jinan University,Guangzhou 510632,China

出　　处：《Aging Communications》2023年第4期9-10,共2页衰老通讯

基　　金：This study was financially supported by the National Natural Science Foundation of China(No.82271563 and No.82204786);The Natural Science Foundation of Guangdong Province of China(No.2022A1515012512);The Academic Promotion Program of Shandong First Medical University.

摘　　要：Parkinson’s disease(PD)is a prevalent neurological disorder around the globe,currently affecting over 6 million people globally[1].It is estimated that by 2040,this number may double to more than 12 million[2].Aging is strongly associated with PD,as it is a significant risk factor for its development[3].Clinically,PD presents with various motor and non-motor signs.Movement-related issues mainly consist of slowed motion,involuntary shaking at rest,stiff muscles,and balance difficulties.At the same time,non-movement-related issues include impaired sense of smell,sleep disturbances,bowel irregularities,feelings of sadness,and problems with the body’s automatic functions[4].The typical pathological features of PD patients include the gradual loss of dopaminergic neurons within the substantia nigra pars compacta,coupled with the buildup ofα-synuclein(α-Syn)in neurons,the aggregates of which form inclusions known as Lewy bodies[5].The A53T mutant of humanα-Syn has a propensity to aggregate,a characteristic closely associated with the neurotoxicity seen in familial PD[6].A synthesis of both in vitro and in vivo research indicates that the misfolding and aggregation ofα-Syn are key pathogenic mechanisms in the development of PD[7-9].

关 键 词：IMPAIRED SHAKING globally 

分 类 号：R74[医药卫生—神经病学与精神病学]