丹参川芎嗪注射液联合阿加曲班注射液对后循环穿支动脉急性脑梗死患者神经功能和脑动脉血流动力学指标的影响  

Effects of salvia miltiorrhiza and ligustrazine injection combined with argatroban on neurological function and hemodynamics in patients with acute cerebral infarction of the perforating artery of the posterior circulation

作　　者：张卓[1] 王云超 王春一 ZHANG Zhuo;WANG Yunchao;WANG Chunyi(Department of Neurology,the Second People's Hospital of Liaocheng,Liaocheng,Shandong 252600;Department of Traditional Chinese Medicine Rehabilitation,the Second People’s Hospital of Liaocheng,Liaocheng,Shandong 252600)

机构地区：[1]山东省聊城市第二人民医院神经内科,山东聊城252600 [2]山东省聊城市第二人民医院中医康复科,山东聊城252600

出　　处：《河北中医》2023年第12期1991-1995,共5页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察丹参川芎嗪注射液联合阿加曲班注射液对后循环穿支动脉急性脑梗死患者神经功能和脑动脉血流动力学指标的影响。方法将89例后循环穿支动脉急性脑梗死患者按照随机数字表法分为2组。对照组44例予阿加曲班注射液治疗,治疗组45例在对照组治疗基础上加丹参川芎嗪注射液治疗。2组均治疗7天。比较2组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)评分、中医证候评分;比较2组治疗前后C反应蛋白(CRP)、同型半胱氨酸(Hcy)水平变化;比较2组治疗前后血流动力学指标变化;比较2组不良反应。结果2组治疗后NIHSS评分较本组治疗前降低(P<0.05),BI评分较本组治疗前升高(P<0.05);治疗后治疗组NIHSS评分低于对照组(P<0.05),BI评分高于对照组(P<0.05)。2组治疗后中医证候各项评分及总评分均较本组治疗前降低(P<0.05),治疗后治疗组中医证候各项评分及总评分均低于对照组(P<0.05)。2组治疗后CRP、Hcy水平均较本组治疗前降低(P<0.05),治疗后治疗组CRP、Hcy水平均低于对照组(P<0.05)。2组治疗后大脑中动脉搏动指数(PI)、阻力指数(RI)均较本组治疗前降低(P<0.05),大脑中动脉收缩期峰值血流速度(PSV)、舒张期末血流速度(EDV)均较本组治疗前升高(P<0.05);治疗后治疗组PI、RI低于对照组(P<0.05),PSV、EDV高于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论丹参川芎嗪注射液联合阿加曲班注射液,可减轻后循环穿支动脉急性脑梗死患者神经功能缺损,提高日常自理能力,可能与降低CRP、Hcy表达和促进脑灌注有关。Objective To observe the effects of salvia miltiorrhiza and ligustrazine injection combined with argatroban on nerve function and hemodynamics in patients with acute cerebral infarction of the perforating artery of the posterior circulation.Methods Eighty-nine patients with acute cerebral infarction of posterior circulation perforator arteries were randomly divided into the control group(n=44)and the treatment group(n=45).All patients were managed by argatroban injection,and the patients in the treatment group were additionally treated with salvia miltiorrhiza and ligustrazine injection.The treatment were conducted for 7 days in the both groups,aiming to compare the score of National Institutes of Health Stroke Scale(NIHSS),Barthel index(BI),traditional Chinese medicine(TCM)syndrome,and the levels of C-reactive protein(CRP)and homocysteine(Hcy),as well as the changes of hemodynamic indicators and adverse reactions between groups before and after treatment.Results Significantly decreased NIHSS scores(P<0.05)and increased BI scores(P<0.05)were found in the both groups.The NIHSS score of the treatment group was significantly lower than that of the control group(P<0.05),and the BI score in the treatment group was significantly higher than that of the control group(P<0.05).After treatment,the each dimension score and total scores of TCM syndromes in the both groups were significantly lower than those before treatment(P<0.05),which were significantly lower in the treatment group than the control group(P<0.05).The levels of CRP and Hcy in the both groups were significantly lower after treatment(P<0.05),and the decrease was more pronounced in the treatment group(P<0.05).Significantly lower pulsatility index(PI)and resistance index(RI)and significantly higher peak systolic velocity(PSV)and end-diastolic velocity(EDV)in middle cerebral artery(MCA)were deceted in the both groups(all P<0.05),the treatment group was superior to the control group for the levels of PI,RI,PSV,and EDV(all P<0.05).There was no statistically signif

关 键 词：脑梗死 中西医结合疗法 注射剂 

分 类 号：R743.305.8[医药卫生—神经病学与精神病学]