丁基苯酞联合巴曲酶治疗脑梗死患者的疗效及对血清HIF-1α及S-100B蛋白的影响研究  

Efficacy of butylphthalide combined with batroxobin on patients with acute cerebral infarction and its influence on serum HIF-1αand S-100B protein

作　　者：夏丽玲 XIA Li-ling(Jilin Provincial Psychiatric Hospital,Siping 136000,China)

机构地区：[1]吉林省精神病医院,136000

出　　处：《中国现代药物应用》2023年第23期1-5,共5页Chinese Journal of Modern Drug Application

摘　　要：目的分析丁基苯酞联合巴曲酶治疗急性脑梗死患者的疗效及对血清人缺氧诱导因子-1α(HIF-1α)及S-100B蛋白的影响。方法60例急性脑梗死患者,根据随机数字表法分为对照组与观察组,每组30例。对照组实施常规治疗,观察组在对照组基础上增加丁基苯酞联合巴曲酶治疗。比较两组脑动脉血流速度、基底动脉血流速度,治疗前后血清超敏C反应蛋白、HIF-1α、S-100B蛋白水平及神经功能缺损评分,治疗效果、不良反应发生情况。结果观察组脑动脉血流速度(65.21±4.21)ml/min、基底动脉血流速度(36.56±3.12)ml/min均大于对照组的(49.51±2.91)、(23.12±2.21)ml/min,差异有统计学意义(P<0.05)。治疗后,两组血清超敏C反应蛋白、HIF-1α、S-100B蛋白水平及神经功能缺损评分均低于本组治疗前,且观察组血清超敏C反应蛋白、HIF-1α、S-100B蛋白水平及神经功能缺损评分分别为(3.56±1.01)mg/L、(220.12±20.23)pg/ml、(0.56±0.13)μg/L、(6.56±1.21)分,显著低于对照组的(6.21±1.21)mg/L、(278.56±35.67)pg/ml、(0.90±0.25)μg/L、(10.53±1.67)分,差异有统计学意义(P<0.05)。观察组治疗总有效率96.67%高于对照组的76.67%,差异有统计学意义(P<0.05)。两组治疗过程中均未见不良反应。结论丁基苯酞联合巴曲酶对于急性脑梗死的治疗效果确切,可改善患者HIF-1α、S-100B蛋白水平及神经功能、预后,且无明显不良反应,值得推广。Objective To analyze the efficacy of butylphthalide combined with batroxobin on patients with acute cerebral infarction and its influence on serum hypoxia-inducible factor-1α(HIF-1α)and S-100B protein.Methods A total of 60 patients with acute cerebral infarction were divided into a control group and an observation group according to random numerical table,with 30 cases in each group.The control group received conventional treatment,and the observation group was treated with butylphthalide and batroxobin on the basis of the control group.Both groups were compared in terms of cerebral artery blood flow velocity,basilar artery blood flow velocity,serum hypersensitive C-reactive protein,HIF-1α,S-100B protein level and neurological deficit score before and after treatment,therapeutic effect and the occurrence of adverse reactions.Results The cerebral artery blood flow velocity of(65.21±4.21)ml/min and basilar artery blood flow velocity of(36.56±3.12)ml/min in the observation group were higher than those of(49.51±2.91)and(23.12±2.21)ml/min in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum hypersensitive C-reactive protein,HIF-1α,S-100B protein and neurological deficit score in both groups were lower than those before treatment in this group;the levels of serum hypersensitive C-reactive protein,HIF-1αand S-100B protein and neurological deficit score in the observation group were(3.56±1.01)mg/L,(220.12±20.23)pg/ml,(0.56±0.13)μg/L and(6.56±1.21)points,which were significantly lower than those of(6.21±1.21)mg/L,(278.56±35.67)pg/ml,(0.90±0.25)μg/L and(10.53±1.67)points in the control group;the differences were statistically significant(P<0.05).The total effective rate of the observation group was 96.67%,which was higher than that of 76.67%of the control group,and the difference was statistically significant(P<0.05).No adverse reactions were observed in both groups during treatment.Conclusion Butylphthalide combined with batroxobin has defin

关 键 词：丁基苯酞 巴曲酶 超静脉溶栓时间窗 急性脑梗死 疗效 人缺氧诱导因子-1α S-100B蛋白 

分 类 号：R743.33[医药卫生—神经病学与精神病学]