齐墩果酸抗肿瘤作用及机制研究进展  

Research progress on anticancer effect and mechanism of oleanolic acid

作　　者：袁彬 韦燕飞 周凤玲 黄德伦 YUAN Bin;WEI Yanfei;ZHOU Fengling;HUANG Delun(College of Basic Medicine,Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning530200,China;Key Laboratory of Traditional Chinese Medicine Pharmacology of Guangxi EducationDepartment,Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning530200,China)

机构地区：[1]广西中医药大学基础医学院,广西南宁530200 [2]广西中医药大学广西高校中药药理重点实验室,广西南宁530200

出　　处：《中国医药导报》2023年第33期60-62,66,共4页China Medical Herald

基　　金：广西高校中青年教师科研基础能力提升项目(2020KY07028);广西壮瑶药重点实验室课题(GXZYKF2020A-04);广西中医药大学博士科研启动基金项目(2018BS012);广西中医药大学青年基金项目(2019QN002);广西中医药大学“岐黄工程”高层次人才团队培育项目(2021001);广西中医药大学校级重点硕士研究生科研创新项目(YCSZ2022001);广西一流学科建设开放课题(2019XK088)。

摘　　要：齐墩果酸(OA)是一种天然五环三萜酸类化合物,其抗肿瘤药理作用突出,具有抗瘤谱广、毒副作用小且来源丰富的独特优势。OA通过与特异性分子靶点相互作用在诱导肿瘤细胞凋亡、抑制肿瘤细胞增殖、抑制肿瘤细胞侵袭和转移,抑制肿瘤血管生成等多方面发挥抗肿瘤作用。其抗肿瘤机制多元化、涉及相关通路因子繁多。积极探索OA抗肿瘤作用的具体分子机制,开发更高活性、易吸收的衍生物对OA应用于肿瘤治疗方面产生重要临床意义。The oleanolic acid(OA)is a natural pentacyclic triterpenoid acid,which has outstanding anticancer pharmacological effects,it has the advantages of broad antitumor spectrum,little side effects and abundant sources.Through the interaction with specific molecular targets,OA plays an anticarcinogenic role in inducing apoptosis,inhibiting proliferation,inhibiting invasion and metastasis,suppressing angiogenesis and so on.Its anti-tumor mechanism is diversified and involves a wide range of related pathway factors.Exploring the specific molecular mechanism of OA antitumor effect and developing higher activity and easy absorption OA derivatives will have important clinical significance on its application for carcinoma therapy.

关 键 词：齐墩果酸 抗肿瘤作用 细胞周期阻滞 细胞凋亡 

分 类 号：R734.2[医药卫生—肿瘤]