C1q/TNF相关蛋白3、基质金属蛋白酶3和基质金属蛋白酶9对绝经后女性骨密度的影响  

Effects of C1q/TNF-related protein 3,matrix metalloproteinase 3,and matrix metalloproteinase 9 on bone mineral density in postmenopausal women

作　　者：卢学超[1] 徐园园[1] 魏迎凤[1] 任亚丽[2] 王霞[3] LU Xuechao;XU Yuanyuan;WEI Yingfeng;REN Yali;WANG Xia(Department of Endocrinology,Nantong Third People’s HospitalNantong Third Hospital Affiliated to Nantong University,Jiangsu Province,Nantong226000,China;Department of Medical Technology,Nantong Health Higher Vocational and Technical School,Jiangsu Province,Nantong226000,China;Department of Osteoporosis,Nantong Third People’s HospitalNantong Third Hospital Affiliated to Nantong University,Jiangsu Province,Nantong226000,China)

机构地区：[1]江苏省南通市第三人民医院南通大学附属南通第三医院内分泌科,江苏南通226000 [2]江苏省南通卫生高等职业技术学校医学技术系,江苏南通226000 [3]江苏省南通市第三人民医院南通大学附属南通第三医院骨质疏松科,江苏南通226000

出　　处：《中国医药导报》2023年第33期109-112,共4页China Medical Herald

基　　金：江苏省自然科学基金面上项目(BK20201445);江苏省南通市卫生和计划生育委员会科研课题(MB2019024)。

摘　　要：目的探究C1q/TNF相关蛋白3(CTRP3)、基质金属蛋白酶(MMP)-3及MMP-9对绝经后女性骨密度的影响。方法回顾性分析2019年6月至2022年6月江苏省南通市第三人民医院进行体检的92名自然绝经女性的临床资料。根据骨密度T评分将其分为健康组及骨质疏松组,骨质疏松定义为骨密度T评分≤-2.5 SD。比较两组CTRP3、MMP-3及MMP-9水平;CTRP3、MMP-3及MMP-9与骨密度的相关性采用Pearson相关性分析;受试者操作特征曲线评估CTRP3、MMP-3、MMP-9对骨质疏松的预测价值。结果骨质疏松组腰椎、股骨颈骨密度及骨矿含量水平均低于健康组(P<0.05)。骨质疏松组CTRP3水平低于健康组,MMP-3、MMP-9水平高于健康组(P<0.05)。CTRP3与腰椎、股骨颈骨密度呈正相关(r=0.451、0.483,P<0.05);MMP-3与腰椎、股骨颈骨密度呈负相关(r=-0.476、-0.439,P<0.05);MMP-9与腰椎、股骨颈骨密度呈负相关(r=-0.508、-0.449,P<0.05)。CTRP3、MMP-3及MMP-9联合预测的曲线下面积高于各指标单独预测。结论CTRP3、MMP-3及MMP-9水平与绝经后女性骨密度存在相关性,能够影响骨密度水平,且CTRP3、MMP-3、MMP-9联合诊断对于骨质疏松有一定的参考价值。Objective To investigate the effects of C1q/TNF-related protein 3(CTRP3),matrix metalloproteinase(MMP)-3,and MMP-9 on bone mineral density in postmenopausal women.Methods The clinical data of 92 women with natural men-opause who underwent physical examination in Nantong Third People’s Hospital of Jiangsu Province from June 2019 to June 2022 were retrospectively analyzed.They were divided into healthy group and osteoporosis group according to bone mineral density T score,osteoporosis was defined as bone mineral density T score≤-2.5 SD.The levels of CTRP3,MMP-3,and MMP-9 were compared between two groups.The correlation between CTRP3,MMP-3,and MMP-9 and bone mineral density was analyzed by Pearson correlation analysis,and the predictive value of CTRP3,MMP-3,and MMP-9 in osteoporosis was evaluated by receiver operation characteristic curve.Results Bone mineral density and bone mineral content of lumbar spine and femoral neck in osteoporosis group were lower than those in healthy group(P<0.05).The level of CTRP3 in osteoporosis group was lower than that in healthy group,and the levels of MMP-3 and MMP-9 in osteoporosis group were higher than those in healthy group(P<0.05).CTRP3 was positively correlated with bone mineral density of lumbar spine and femoral neck(r=0.451,0.483,P<0.05);MMP-3 was negatively correlated with bone mineral density of lumbar spine and femoral neck(r=-0.476,-0.439,P<0.05);MMP-9 was negatively correlated with bone mineral density of lumbar spine and femoral neck(r=-0.508,-0.449,P<0.05).The area under the curve predicted jointly by CTRP3,MMP-3,and MMP-9 was higher than that predicted by each index alone.Conclusion CTRP3,MMP-3,and MMP-9 levels are correlated with bone mineral density in postmenopausal women and can affect BMD levels,and the combined diagnosis of CTRP3,MMP-3,and MMP-9 has certain reference value for osteoporosis.

关 键 词：C1q/TNF相关蛋白3 基质金属蛋白酶3 基质金属蛋白酶9 骨密度 骨质疏松 绝经 

分 类 号：R589[医药卫生—内分泌]