自拟滋阴疏肝明目方治疗肝肾阴虚型干眼症患者的临床效果  

Clinical effect of self-made Ziyin Shugan Mingmu Prescription on patients with xerophthalmia with syndrome of yin deficiency of liver and kidney

作　　者：杨磊[1] 吴晓阳[1] 罗继红[1] 薛林平 李杜军[1] YANG Lei;WU Xiaoyang;LUO Jihong;XUE Linping;LI Dujun(Department of Ophthalmology,Hubei Provincial Hospital of Traditional Chinese Medicine,Hubei Province,Wuhan 430074,China;the First Clinical College,Hubei University of Traditional Chinese Medicine,Hubei Province,Wuhan 430061,China)

机构地区：[1]湖北省中医院眼科,湖北武汉430074 [2]湖北中医药大学第一临床学院,湖北武汉430061

出　　处：《中国医药导报》2023年第33期117-121,共5页China Medical Herald

基　　金：湖北省教育厅科学技术研究项目(D20112004)。

摘　　要：目的 观察自拟滋阴疏肝明目方治疗肝肾阴虚型干眼症患者的临床效果。方法 将2019年5月至2021年4月在湖北省中医院眼科就诊的65例肝肾阴虚型干眼症患者按照随机数字表法分为对照组32例,联合组33例。对照组予玻璃酸钠滴眼液联合针刺治疗,联合组在对照组的治疗基础上予自拟滋阴疏肝明目方。以10 d为1个疗程,2个疗程后,比较两组临床疗效。比较两组治疗前后中医症状积分、泪膜破裂时间(BUT)、泪液分泌量、角膜荧光素染色(FL)积分的变化。结果 联合组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组中医症状积分、FL积分均低于治疗前,且联合组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组BUT长于治疗前,泪液分泌量均高于治疗前,且联合组BUT长于对照组,泪液分泌量均高于对照组,差异有统计学意义(P<0.05)。结论 在玻璃酸钠滴眼液联合针刺治疗基础上加用自拟滋阴疏肝明目方,对肝肾阴虚型干眼症患者临床症状及指标具有治疗作用,突出了针药并用治疗眼病的优势,值得进一步推广应用。Objective To observe the clinical effect of self-made Ziyin Shugan Mingmu Prescription on patients with xerophthalmia with syndrome of yin deficiency of liver and kidney.Methods A total of 65 patients with xerophthalmia with syndrome of yin deficiency of liver and kidney treated in the Department of Ophthalmology,Hubei Provincial Hospital of Traditional Chinese Medicine from May 2019 to April 2021 were divided into control group(32 cases)and combination group(33 cases)according to random number table method.The control group was treated with Sodium Hyaluronate Eye Drops combined with acupuncture,and the combined group was treated with self-made Ziyin Shugan Mingmu Prescription on the basis of the treatment of control group.Ten days was taken as a course of treatment,and after two courses of treatment,the clinical efficacy of the two groups was compared.The changes of traditional Chinese medicine symptom score,breakup time of tear film(BUT),tear secretion,and corneal fluorescein staining(FL)scores before and after treatment were compared between the two groups.Results The clinical effect of the combined group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the traditional Chinese medicine symptom scores and FL scores of the two groups were lower than those before treatment,and those of combined group were lower than those of control group,the differences were statistically significant(P<0.05).After treatment,the BUT in both groups were longer than those before treatment,and the tear secretion were higher than those before treatment,and the BUT in the combined group was longer than that in the control group,and the tear secretion was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion On the basis of Sodium Hyaluronate Eye Drops combined with acupuncture,the self-made Ziyin Shugan Mingmu Prescription has therapeutic effect on the clinical symptoms and indicators of patients with xerophthalmia with

关 键 词：自拟滋阴疏肝明目方 肝肾阴虚型 干眼症 针药并用 

分 类 号：R771[医药卫生—眼科]