口服复方泛影葡胺对女性盆腔肿瘤患者放射治疗计划剂量及验证通过率的影响  

Effect of oral compound meglumine diatrizoate on the dose and verification pass rate of radiotherapy plan of female patients with pelvic tumor

作　　者：吴青南 杨雨岩 孙博 WU Qing-nan;YANG Yu-yan;SUN Bo(Department of Radiotherapy,The Peking University International Hospital,Beijing 102206,China;不详)

机构地区：[1]北京大学国际医院放疗科,北京102206

出　　处：《中国医学装备》2023年第12期42-45,共4页China Medical Equipment

摘　　要：目的:探究女性盆腔肿瘤患者口服造影剂辅助勾画肿瘤及危及器官时,对放射治疗计划剂量分布及验证γ通过率的影响。方法:选取医院收治的15例女性盆腔肿瘤患者,每例患者的原始CT图像为口服造影剂图像,基于此图像设计7野静态调强计划为plan1。修正原始图像中肠道的CT值,模拟未服用造影剂的情况得到新图像,使用与plan1相同的优化参数,设计7野静态调强计划为plan2。将两种计划在靶区中心点归一到100%剂量覆盖95%体积,统计最大剂量(D_(max))等9项剂量分布参数以及2项验证参数,评估造影剂的影响。结果:plan1与plan2靶区D_(max)分别为(5457.9±46.41)cGy和(5455.8±46.33)cGy,平均剂量(D_(mean))分别为(5185.4±24.39)cGy和(5189.4±22.78)cGy,适形指数(CI)分别为1.03±0.03和1.03±0.03,其差异均无统计学意义(P>0.05)。3%/3 mm标准下γ通过率分别为99.17±0.44和98.93±0.81,2%/2 mm标准下γ通过率分别为95.46±1.27和94.88±1.87,其差异均无统计学意义(P>0.05)。结论:基于有无服用造影剂的图像所设计出的两种计划的剂量参数和验证参数均无统计学差异。造影剂对女性盆腔肿瘤患者静态调强计划剂量分布和验证通过率未造成统计学影响。Objective:To explore the effect of oral contrast agent on the dose distribution and verification pass rate of radiotherapy plan when female patients with pelvic tumor underwent oral contrast agent to assist the delineations for tumors and organ at risk(OAR).Methods:A total of 15 female patients with pelvic tumor were selected.The original computed tomography(CT)images of each patient were the images with oral contrast agent.Based on these images,a 7-field static intensity-modulated radiotherapy plan was designed as plan 1.The intestinal CT values of the original images were modified to simulate the situations without oral contrast agent to obtain new images.The same optimization parameters of plan 1 was used to design a 7-field static intensity-modulated radiotherapy plan as plan 2.The two kinds of plans were normalized to a degree which 95%of volume was covered by 100%dose at the central point of target region.The 9 parameters of dose distribution included the maximum dose(D_(max)),and two verification parameters were calculated as statistical method,and then,the effect of contrast agent was assessed.Results:The D_(max) values of the target regions of plan 1 and plan 2 were respectively(5457.9±46.41)and(5455.8±46.33).The mean dose(D_(mean))values of them were respectively(5185.4±24.39)and(5189.4±22.78).The conformity index(CI)values of them were respectively 1.03±0.03 and(1.03±0.03).Theγ(3%/3 mm)pass rates of them were respectively(99.17±0.44)and(98.93±0.81)(P=0.177).Theγ(2%/2 mm)pass rates of them were(95.46±1.27)and(94.88±1.87)(P=0.143).The differences of the dose and verification parameters between the designed two plans on the basis of the images with and without oral contrast agent were not statistical significance(P>0.05).Conclusion:Contrast agent does not have statistical effect on the dose distribution and verification pass rate of static intensity-modulated radiotherapy plan for female patients with pelvic tumor.

关 键 词：调强放射治疗 盆腔肿瘤 口服造影剂 剂量比较 剂量验证 

分 类 号：R737.3[医药卫生—肿瘤] R812[医药卫生—临床医学]