术前三维适形放射治疗对结肠癌的疗效及其对血小板参数的影响  

Influences of preoperative 3DCRT on the curative effect and platelet parameters of colon cancer

作　　者：张玉英[1] 孙成林[2] 马骏[2] 杨峰[1] ZHANG Yu-ying;SUN Cheng-lin;MA Jun(Department of Radiology,Affiliated Central Hospital of Shenyang Medical College,Shenyang 110024,China;不详)

机构地区：[1]沈阳医学院附属中心医院放射线科,辽宁沈阳110024 [2]沈阳医学院附属中心医院普外科,辽宁沈阳110024

出　　处：《中国医学装备》2023年第12期67-70,共4页China Medical Equipment

基　　金：辽宁省科学技术计划(20180550600)“结直肠癌CT-26/VCR/L-OHP耐药细胞株的建立及差异表达miRNA筛选与功能分析”。

摘　　要：目的:分析术前三维适形放射治疗(3DCRT)对结肠癌的疗效及对血小板(PLT)参数的影响。方法:选取医院收治的110例结肠癌患者,根据治疗方式不同将其分为对照组(62例)和观察组(58例),对照组给予常规放射治疗,观察组给予术前3DCRT治疗,对比两组放射治疗前后PLT参数指标,统计随访放射治疗后1~3年的局部控制率、生存率及治疗期间并发症发生率。结果:放射治疗后,两组患者PLT及其平均体积(MPV)均低于治疗前,差异有统计学意义(t观察组=7.407,t=5.733;t对照组=4.977,t=2.589;P<0.05)。放射治疗后,观察组PLT、MPV及降钙素原(PCT)值低于对照组,差异有统计学意义(t=2.256,t=4.165,t=2.737;P<0.05)。观察组随访1年、2年及3年的局部控制率及生存率均高于对照组,差异均有统计学意义(χ^(2)局部控制率=4.359,χ^(2)=3.944,χ^(2)=3.910;χ^(2)生存率=3.986,χ^(2)=4.270,χ^(2)=0.011;P<0.05)。两组患者治疗期间白细胞减少率、晚期并发症发生率及全身反应发生率比较,差异均无统计学意义(χ^(2)=0.187,χ^(2)=0.006,χ^(2)=0.011;P>0.05)。结论:术前3DCRT治疗结肠癌可获得更高的肿瘤切除率,可有效调节血小板参数,并明显改善局部控制率及生存率,放射治疗相关不良反应发生率较低,患者可耐受。Objective:To analyze the influences of preoperative three-dimensional conformal radiation therapy(3DCRT)on the curative effect and platelet parameters of colon cancer.Methods:A total of 110 patients with colon cancer admitted to hospital were selected and they were divided into a control group(62 cases)and an observation group(58 cases)according to different treatment methods.The control group was given conventional radiotherapy,and the observation group was given preoperative 3DCRT.The platelet parameters before and after radiotherapy were compared between the two groups.And then,the follow-up was conducted for the local control rate,survival rate and the incidence rate of complication during 1-3 years treatment after radiotherapy,and the results were counted as statistic methods.Results:Platelet(PLT)and mean platelet volume(MPV)of two groups after treatment were significantly lower than those before treatment(tobservation group=7.407,t=5.733,tcontrol group=4.977,t=2.589,P<0.05),respectively.After radiotherapy,the PLT,MPV and procalcitonin(PCT)levels of observation group were significantly lower than those of control group(t=2.256,t=4.165,t=2.737,P<0.05),respectively.The local control rate and survival rate at 1,2 and 3 years of follow-up of the observation group were significantly higher than those of the control group,and the differences were statistically significant(χ^(2) local control rate=4.359,χ^(2)=3.944,χ^(2)=3.910,χ^(2) survival rate=3.986,χ^(2)=4.270,χ^(2)=0.011,P<0.05),respectively.There were no significant differences in the reduction rate of white blood cell,the incidence of advanced complications and the incidence of systemic reactions during treatment between two groups(χ^(2)=0.187,χ^(2)=0.006,χ^(2)=0.011,P>0.05).Conclusion:Preoperative 3DCRT can achieve higher resection rate of tumor in treating colon cancer,which can effectively regulate platelet parameters,and significantly improve local control rate and survival rate in the treatment of colon cancer.The incidence of the relative adve

关 键 词：术前三维适形放射治疗(3DCRT) 结肠癌 疗效 血小板(PLT)参数 

分 类 号：R735.35[医药卫生—肿瘤]