Germ-free, carefree: injured skin uses IL-24 to kick-start repair independent of pathogen-recognition  

作　　者：Ruben A.Ferrer Marta Torregrossa Sandra Franz 

机构地区：[1]Department of Dermatology,Allergology and Venerology,University Leipzig,Leipzig,Germany

出　　处：《Signal Transduction and Targeted Therapy》2023年第11期5129-5131,共3页信号转导与靶向治疗（英文）

摘　　要：Skin injury releases damage-associated molecular patterns(DAMPs)represented by tissue-components and intracellular contents as well as changes in the levels of certain molecules and metabolites that signal the“non-homeostatic”state of the tissue.In addition,microorganisms entering a wound release molecules,which are sensed as“non-self”(pathogen-associated molecular patterns,PAMPs).Together,DAMPs and PAMPs initiate a complex and coordinated repair process aimed at restoring homeostasis.The exciting work from Liu et al.reports of an additional novel mechanism by which a“non-homeostatic”state in murine cutaneous wounds elicits a response through IL-24 to mediate repair(Fig.1).

关 键 词：wound HOMEOSTASIS release 

分 类 号：R751[医药卫生—皮肤病学与性病学]