Cephalopod RNA recoding: linking protein plasticity to thermal adaptation and catalyzing beyond-species protein characterization  

作　　者：Junyi Wang Guoping Li Min Wu 

机构地区：[1]Laboratory of Allergy and Precision Medicine,Department of Pulmonary and Critical Care Medicine,Chengdu Institute of Respiratory Health,The Third People’s Hospital of Chengdu,Affiliated Hospital of Southwest Jiaotong University,Chengdu,China [2]State Key Laboratory of Quality Research in Chinese Medicine,Macao University of Science and Technology,Taipa,Macao SAR,China [3]Wenzhou Institute,University of Chinese Academy of Sciences,325000,Wenzhou,Zhejiang,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第11期5146-5148,共3页信号转导与靶向治疗（英文）

基　　金：the National Natural Science Foundation of China(81970026,82000029,82200079);the National Key Clinical Specialist Construction Project(2023031L);the Natural Science Foundation of Sichuan(2022NSFSC1324,23NSFSC1736);the Chengdu High-level Key Clinical Specialty Construction Project(ZX20201202020);Wenzhou Institute of University of Chinese Academyof Sciences。

摘　　要：A recent publication in Cell by Rangan et al.highlights the remarkable ability of squids to dynamically regulate the function of microtubule motor proteins through RNA recoding in response to ocean temperature fluctuations(Fig.1).This study not only provides valuable insights into the crucial role of RNA recoding in generating protein plasticity for adapting to ever-changing environmental conditions but also presents an unprecedented methodology facilitating characterization of conserved non-cephalopod proteins,particularly in the realm of human health and disease.1 Fig.

关 键 词：PLASTICITY characterization 

分 类 号：Q51[生物学—生物化学]