Unmasking metabolic dependencies in pancreatic cancer: aberrant polyamine synthesis as a promising new therapeutic target  

作　　者：Gerrit Wolters-Eisfeld Thilo Hackert Cenap Güngör 

机构地区：[1]Department of General,Visceral and Thoracic Surgery,University Medical Center Hamburg-Eppendorf,Hamburg,Germany

出　　处：《Signal Transduction and Targeted Therapy》2023年第11期5151-5152,共2页信号转导与靶向治疗（英文）

摘　　要：In a recently published Nature article,Lee et al.investigated distinct metabolic dependencies of pancreatic ductal adenocarcinoma(PDA)cells compared to normal tissue,and discovered that PDA cells exhibited a unique reliance on de novo ornithine synthesis from glutamine,rather than arginine.This aberrant polyamine synthesis offers a promising therapeutic target for pancreatic cancer.

关 键 词：SYNTHESIS DEN depen 

分 类 号：R730.5[医药卫生—肿瘤]