伴强迫症状与不伴强迫症状抑郁症患者人格特征与认知功能的差异  

The differences of personality characteristics and cognitive functions in depression patients with obsessive-compulsive symptoms and without obsessive-compulsive symptoms

作　　者：陈妍荻 严舒雅 叶恺唯 钟舒明[1] 贾艳滨[1] Chen Yandi;Yan Shuya;Ye Kaiwei;Zhong Shuming;Jia Yanbin(Department of Psychiatry,First Affiliated Hospital of Jinan University,Guangzhou 510630,China;School of Management,Jinan University,Guangzhou 510632,China)

机构地区：[1]暨南大学附属第一医院精神医学科,广州510630 [2]暨南大学管理学院,广州510632

出　　处：《中华行为医学与脑科学杂志》2023年第12期1086-1092,共7页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金(82271564);广州市科技计划项目(202201020047)。

摘　　要：目的探讨伴强迫症状抑郁症患者与不伴强迫症状抑郁症患者人格特征与认知功能的差异。方法于2020年10月至2021年10月纳入31例伴强迫症状的抑郁症患者、29例不伴强迫症状的抑郁症患者和30名健康对照(对照组),使用艾森克人格个性问卷(Eysenck personality questionnaire,EPQ)、人格障碍诊断问卷(第4版)(personality diagnostic questionnaire-4,PDQ-4)和明尼苏达多项人格调查问卷(Minnesota multiphasic personality inventory,MMPI)评估3组研究对象的人格特征,采用认知功能评估成套测验(MCCB)共识版评估认知功能。采用SPSS 25.0软件进行数据处理,使用单因素方差分析和简单效应分析比较3组研究对象的人格特征和认知功能的差异。结果EPQ得分比较显示,伴与不伴强迫症状组的精神质得分[(50.32±10.08)分,(49.83±11.69)分]均显著低于对照组[(59.47±10.41)分](P=0.004,0.003),神经质得分[(61.94±12.36)分,(63.10±10.56)分]均显著高于对照组[(46.13±8.33)分](均P<0.05)。PDQ-4得分比较显示,伴强迫症状组[5.00(2.00,7.00)分]分裂型得分显著高于不伴强迫症状组[3.00(1.00,5.00)分](P=0.024)。MMPI得分比较显示,除男-女子气和轻躁狂两个维度,伴与不伴强迫症状组的其他8个维度得分均显著高于对照组(均P<0.01)。MCCB得分比较显示,伴强迫症状组的注意/警觉性和视觉学习得分显著低于对照组(P=0.042,0.004),但伴与不伴强迫症状抑郁症患者MCCB各维度得分差异无统计学意义(均P>0.05)。结论伴与不伴强迫症状抑郁症患者人格特征和认知功能均与健康对照存在差异。伴与不伴强迫症状抑郁症患者的分裂型人格特征存在差异,而认知功能未见明显差异。提示伴强迫症状的抑郁症患者较单纯抑郁症状患者可能存在较多偏离常态的人格特征,而认知功能损害的差异未来仍需进一步探讨。ObjectiveTo investigate the differences in personality characteristics and cognitive functions in depression patients with and without obsessive-compulsive.MethodsFrom October 2020 to October 2021,31 patients diagnosed as major depressive disorder(MDD)with obsessive-compulsive symptoms(OCS),totally 29 patients diagnosed as MDD without OCS,and 30 healthy controls(HC group)were recruited.The personality characteristics of all subjects were assessed with Eysenck personality questionnaire(EPQ),personality diagnostic questionnaire-4(PDQ-4)and Minnesota multiphasic personality inventory(MMPI),while cognitive functions were assessed with measurement and treatment research to improve cognition in schizophrenia(MATRICS)consensus cognitive battery(MCCB).SPSS 25.0 software was used for data processing,and univariate analysis of variance and simple effect analysis were used to compare the differences in personality characteristics and cognitive functions among the three groups of subjects.ResultsThe comparison of EPQ scores showed that the psychoticism scores of the group with and without OCS((50.32±10.08),(49.83±11.69))were significantly lower than that of the HC group(59.47±10.41)(P=0.004,0.003),while the neuroticism scores((61.94±12.36),(63.10±10.56))were significantly higher than that of the HC group(46.13±8.33)(both P<0.05).The comparison of PDQ-4 scores showed that the schizoid score of the group with OCS(5.00(2.00,7.00))was significantly higher than that of the group without OCS(3.00(1.00,5.00))(P=0.024).The comparison of MMPI scores showed that except for the two dimensions of masculinity-femininity and hypomania,the scores of the other eight dimensions in the group with and without OCS were significantly higher than those in the HC group(all P<0.01).The comparison of MCCB scores showed that the attention/alertness and visual learning scores of the group with OCS were significantly lower than those of the HC group(P=0.042,0.004),meanwhile there was no difference of the all dimension scores of MCCB between the M

关 键 词：抑郁症 强迫症状 人格特征 认知功能 

分 类 号：R749[医药卫生—神经病学与精神病学]