PIKFYVE Inhibition,A Neuronal“Emetic”for Treating ALS?  

作　　者：Wenkai Yue Connie WTang Yanshan Fang 

机构地区：[1]Interdisciplinary Research Center on Biology and Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai,201203,China [2]University of Chinese Academy of Sciences,Beijing,100049,China [3]Department of Psychology,Wellesley College,Wellesley,MA,02481,USA

出　　处：《Neuroscience Bulletin》2023年第11期1738-1740,共3页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(32270812 and 31970697);the Science and Technology Commission of Shanghai Municipality(201409003300,2019SHZDZX02,and 20490712600).

摘　　要：The processes maintaining protein homeostasis(also known as"proteostasis")are crucial for the normal functions and survival of cells.A key process regulating cellular proteostasis is protein turnover.The conventional pathways mediating protein turnover are the ubiquitin-proteasome system(UPS)and autophagy[1,2].When these mechanisms are impaired—such as in diseased conditions or during aging——misfolded proteins accumulate.

关 键 词：IMPAIRED STASIS HOMEOSTASIS 

分 类 号：R338[医药卫生—人体生理学]