Construction of 3,9-diazatetraasteranes and 3,9-diazatetracyclododecanes by photocycloaddition reaction of 1,4-dihydropyridines:Experimental and theoretical investigation  

作　　者：Runzhi Sun Xiuqing Song Shijie Wang Xiaokun Zhang Hong Yan Yeming Wang 

机构地区：[1]Faculty of Environment and Life,Beijing University of Technology,Bejing 100124,China [2]Large-scale Instruments and Equipments Sharing Platform,Beijing University of Technology,Beijing 100124,China [3]Beijing Tide Pharmaceutical Co.,Ltd.,Beijing 100176,China

出　　处：《Chinese Chemical Letters》2023年第12期177-182,共6页中国化学快报（英文版）

基　　金：supported by the Beijing Natural Science Foundation(No.2192004).

摘　　要：A photocycloaddition reaction of ethyl 1,4-diaryl-1,4-dihydropyridine-3-carboxylate for the construction of 3,9-diazatetraasteranes(Pr)and 3,9-diazatetracyclododecanes(P2)is reported for the first time.The types of reaction product clearly differ with solvent,regardless of the irradiation wavelength.The difference in Pi and P2 lies in the second step of the intramolecular[2+2]photocyclization.In order to further investigate this phenomenon and gain a deeper understanding of the photochemical behavior of 1,4-dihydropyridines,DFT and TDDFT theoretical calculations are performed.The results provide a good explanation for the formation of 3,9-diazatetraasteranes and 3,9-diazatetracyclododecanes.

关 键 词：1 4-DIHYDROPYRIDINE PHOTOCYCLOADDITION Theoretical investigation 3 9-Diazatetracyclododecanes 

分 类 号：O621.256.7[理学—有机化学] O626[理学—化学]