左乙拉西坦联合氯硝西泮对儿童良性癫痫伴中央颞区棘波脑电图特征及生活质量的影响  

Effect of levetiracetam combined with clonazepam on electroencephalogram characteristics and quality of life in children with benign epilepsy with centrotemporal spikes

作　　者：王沾 王芳 刘春红 管刘娟 Wang Zhan;Wang Fang;Liu Chunhong;Guan Liujuan(Department of Pediatrics,Zhoukou Maternal and Child Health Hospital,Zhoukou 466000,China)

机构地区：[1]周口市妇幼保健院儿科,周口466000

出　　处：《中国临床实用医学》2023年第5期28-32,共5页China Clinical Practical Medicine

摘　　要：目的:探讨左乙拉西坦联合氯硝西泮对儿童良性癫痫伴中央颞区棘波(BECTS)脑电图特征及生活质量的影响。方法:本研究为随机对照研究,选取2019年1月至2022年11月周口市妇幼保健院儿科收治的64例BECTS患儿,男25例,女39例,年龄(9.98±1.01)岁,年龄范围为7~14岁。采用随机数表法将患儿随机分为左乙拉西坦组与氯硝西泮组,每组32例。左乙拉西坦组患儿采用左乙拉西坦治疗,氯硝西泮组患儿采用左乙拉西坦联合氯硝西泮治疗,比较两组患儿治疗效果、治疗后及随访时脑电图特征、治疗前后血清因子[同型半胱氨酸(Hcy)、二甲基精氨酸(ADMA)、胱抑素C]水平及智力水平[韦氏儿童智力量表评估]及生活质量[癫痫患者生活质量评定量表-31(QOLIE-31)评估]。结果:氯硝西泮组治疗有效率[93.8%(30/32)]高于左乙拉西坦组[71.9%(23/32)],差异有统计学意义( P<0.05)。治疗后,氯硝西泮组正常范围率[50.0%(16/32)]高于左乙拉西坦组[25.0%(8/32)];随访结束时,氯硝西泮组正常范围率[90.6%(29/32)]高于左乙拉西坦组[68.8%(22/32)],差异有统计学意义( P<0.05)。治疗后,氯硝西泮组患儿胱抑素C水平[(1.10±0.18)mg/L]低于左乙拉西坦组[(1.21±0.24)mg/L],氯硝西泮组患儿总智商[(105.51±2.32)分]及QOLIE-31评分[(68.79±4.32)分]高于左乙拉西坦组[(100.31±2.77)分、(63.20±5.15)分],差异有统计学意义( P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义( P>0.05)。 结论:左乙拉西坦联合氯硝西泮治疗BECTS患儿效果确切,能改善患儿智力水平及生活质量,用药较安全可靠,利于预后。ObjectiveTo investigate the effect of levetiracetam combined with clonazepam on electroencephalogram(EEG)characteristics and quality of life in children with benign epilepsy with centrotemporal spikes(BECTS).MethodsThis study was a randomized controlled study,a total of 64 patients with BECTS were selected from the department of Pediatrics in Zhoukou Maternal and Child Health Hospital from January 2019 to November 2022,including 25 males and 39 females,aged(9.98±1.01)years old,ranging form 7 to 14 years old.The patients were randomly divided into levetiracetam group and clonazepam group,there were 32 cases in each group.The patients in levetiracetam group were treated with levetiracetam,the children in the clonazepam group were treated with levetiracetam and clonazepam.The therapeutic effect,electroencephalogram(EEG)characteristics,serum factor level[homocysteine(Hcy),asymmentric dimethylarginine(ADMA),cystatin C],intelligence level(wechsler intelligence scale for children assessment)and quality of life[quality of life inpeople with epilepsy-31(QOLIE-31)]before and after treatment were compared between the two groups.ResultsThe effective rate of clonazepam group[93.8%(30/32)]was higher than that of levetiracetam group[71.9%(23/32)],and the difference was statistically significant(P<0.05).After treatment,the normal range rate of clonazepam group[50.0%(16/32)]was higher than that of levetiracetam group[25.0%(8/32)],at the end of follow-up,the normal range rate of clonazepam group[90.6%(29/32)]was higher than that of levetiracetam group[68.8%(22/32)],and the differences were statistically significant(P<0.05).After treatment,cystatin C level in clonazepam group[(1.10±0.18)mg/L]was lower than that in levetiracetam group[(1.21±0.24)mg/L].The total IQ[(105.51±2.32)points]and QOLIE-31 score[(68.79±4.32)points]of the clonazepam group were higher than those of the levetiracetam group[(100.31±2.77)points,(63.20±5.15)points],and the differences were statistically significant(P<0.05).There was no significant difference

关 键 词：左乙拉西坦 氯硝西泮 儿童良性癫痫伴中央颞区棘波 脑电图特征 

分 类 号：R742.1[医药卫生—神经病学与精神病学]