染料木素抗结直肠癌分子机制的研究进展  

Progress on the molecular mechanism of genistein against colorectal cancer

作　　者：邱媛 莫中成 陈燕华 卢恒哲 于宗超 刘引 刘龙飞[1] QIU Yuan;MO Zhongcheng;CHEN Yanhua;LU Hengzhe;YU Zongchao;LIU Yin;LIU Longfei(Surgery Department of Nan Hua Hospital Affiliated to Nan Hua University,Hengyang 421002,China;Organization and Embryology Teaching and Research Department,Basic Medical Research Institute,School of Basic Medicine,Guilin Medical College,Guilin 541199,China)

机构地区：[1]南华大学附属南华医院普外科,衡阳421002 [2]桂林医学院基础医学院组织胚胎教研室,基础医学研究所,桂林541199

出　　处：《生命的化学》2023年第11期1750-1757,共8页Chemistry of Life

基　　金：湖南省自然科学基金项目(2020JJ4552)。

摘　　要：结直肠癌是世界范围内的恶性肿瘤,发病率逐年上升,预后差且尚无有效治疗药物。迫切需要探索挖掘结直肠癌发生发展的机制及寻找新的治疗药物。染料木素已被大量研究证明可用于结直肠癌的治疗。它是一种多酚异黄酮化合物,大量存在于大豆或大豆制品中,在亚洲人群中被广泛食用。具有多种生物活性,包括抗糖尿病、抗炎症、抗肥胖和抗血管生成、心脏保护功能及抗癌,其中抗癌作用研究最为广泛。染料木素抗结直肠癌的分子机制涉及多个方面:抑制肿瘤细胞增殖、侵袭及迁移,抗凋亡、氧化应激和炎症等。本文将围绕以上几个方面展开论述,将近年研究成果进行总结,以开发具有良好抗癌潜力的新型治疗药物,为结直肠癌的治疗提供理论基础。Colorectal cancer is a worldwide malignant tumor with increasing incidence,poor prognosis and no effective therapeutic agents.There is an urgent need to explore the mechanisms underlying the development of colorectal cancer and to find new therapeutic agents.Genistein has been shown in numerous studies to be used in the treatment of colorectal cancer.It is a polyphenol isoflavone compound found in large quantities in soybeans or soy products and is widely consumed in Asian populations.It has a variety of biological activities,including diabetic,anti-inflammatory,anti-obesity and anti-angiogenesis,cardioprotective function and anticancer,of which the anticancer effect has been most widely studied.The molecular mechanism of genistein against colorectal cancer involves several aspects:inhibition of tumor cell proliferation,invasion and migration,anti-apoptosis,oxidative stress and inflammation.This review will focus on the above aspects.The research results of recent years will be summarized in order to develop novel therapeutic drugs with good anticancer potential and provide a theoretical basis for the treatment of colorectal cancer.

关 键 词：结直肠癌 染料木素 拓扑异构酶 

分 类 号：R735.3[医药卫生—肿瘤]