癌性恶病质诊断、评估及治疗进展  

Research progress of pathogenesis,diagnosis and treatment of cancer cachexia

作　　者：许家豪 王俊杰 谈善军 吴国豪[1,2] XU Jia-hao;WANG Jun-jie;TAN Shan-jun;WU Guo-hao(Shanghai Clinical Nutrition Research Center,Shanghai 200032,China;Department of General Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]上海市临床营养研究中心,上海200032 [2]复旦大学附属中山医院普通外科,上海200032

出　　处：《中国临床医学》2023年第6期1074-1079,共6页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金(81900484).

摘　　要：癌性恶病质是一类复杂的代谢综合征,包括肌肉消耗、脂肪消耗、非计划的体质量下降、厌食和免疫功能破坏等。恶病质可显著降低肿瘤患者的抗肿瘤治疗疗效,增加治疗不良反应,加重患者的症状负担,影响患者的生活质量,并最终缩短患者的生存时间。本文对癌性恶病质的诊断、临床评估以及治疗的研究进展进行综述。Cancer cachexia is a complex metabolic syndrome which is characterized by muscle wasting,fat decomposition,unplanned weight loss,anorexia and immune dysfunction.Cachexia can significantly reduce the efficacy of antitumor therapies and increase treatment-related toxicity in cancer patients.It increases the symptom burden of patients,affects the quality of their life,ultimately shortens their survival time.This article reviews the research progress of diagnosis and treatment of cancer cachexia.

关 键 词：恶病质 恶性肿瘤 诊断 评估 治疗 

分 类 号：R730[医药卫生—肿瘤]