环状RNA在食管癌诊断和预后中的研究进展  

Research Progress of CircRNA in Diagnosis and Prognosis of Esophageal Cancer

作　　者：马丽霞 左志向 石林林 李佳怡 喻莹 谷变利 鲁智豪[3] 高社干[1] MA Lixia;ZUO Zhixiang;SHI Linlin;LI Jiayi;YU Ying;GU Bianli;Lu Zhihao;GAO Shegan(Henan Key Laboratory of Cancer Epigenetics,Cancer Institute,First Affiliated Hospital,College of Clinical Medicine of Henan University of Science and Technology,Luoyang,China,471003;Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine,Guangzhou,China,510060;Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Gastrointestinal Oncology,Peking University Cancer Hospital and Institute,Beijing,China,100142)

机构地区：[1]河南科技大学临床医学院,河南科技大学第一附属医院,河南科技大学肿瘤研究所,河南省肿瘤表观遗传重点实验室,中国洛阳471003 [2]中山大学肿瘤防治中心,华南肿瘤学国家重点实验室暨肿瘤医学协同创新中心,中国广州510060 [3]北京大学肿瘤医院暨北京市肿瘤防治研究所消化肿瘤内科,恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142

出　　处：《食管疾病》2023年第4期241-249,共9页Journal of Esophageal Diseases

基　　金：河南省医学科技攻关省部共建重点项目(SBGJ202102199);河南省重点研发与推广专项(科技攻关)项目(22210231010115);洛阳市社会发展专项医疗卫生重点项目(2101038A)。

摘　　要：环状RNA(circular RNA,circRNA)是一种新型内源性环状结构的非编码RNA,受顺式调控元件和相关蛋白反式调控,经“反向剪接”机制产生。circRNA在基因剪接、转录、染色质修饰、miRNA海绵作用及蛋白捕获等方面发挥重要作用。circRNA高度稳定,且在不同组织中差异表达。circRNA异常表达与肿瘤发生和转移相关。然而,食管癌中具有重要功能的circRNA及作用机制目前尚不清楚。本文结合circRNA的功能特点,对circRNA在食管癌发生发展中的作用及其作为食管癌诊断、预后分子标志物的研究进展做一综述。Circular RNA(circRNA)is a novel endogenous circular structured non-coding RNA,which is regulated by cis-acting elements and related proteins in trans by a“back-splicing”mechanism.CircRNA plays an important role in gene splicing,transcription,chromatin modification,miRNA sponge action and protein capture.CircRNA are highly stable and differentially expressed in different tissues.CircRNA aberrant expression is associated with tumourigenesis and metastasis.However,circRNAs with important functions in esophageal cancer and their mechanisms of action are still unclear.In this paper,we review the role of circRNA in the development of esophageal cancer and its research progress as a diagnostic and prognostic marker of esophageal cancer,taking into account the functional characteristics of circRNA.

关 键 词：食管癌 环状RNA 分子标志物 

分 类 号：R731.5[医药卫生—肿瘤]