IRBIT在人食管癌组织中表达状况的初步研究  

Expression of IRBIT in Human Esophageal Carcinoma

作　　者：金哲[1] 吴利娟[1] 邢鲁奇[1] 金建军[1] JIN Zhe;WU Lijuan;XING Luqi;JIN Jianjun(The First Affiliated Hospital,College of Clinical Medicine of Henan University of Science and Technology,Luoyang,China,471003)

机构地区：[1]河南科技大学临床医学院,河南科技大学第一附属医院,中国洛阳471003

出　　处：《食管疾病》2023年第4期260-262,278,共4页Journal of Esophageal Diseases

基　　金：河南省医学科技攻关项目(201504018)。

摘　　要：目的调查IRBIT(IP3受体结合蛋白)在食管癌组织中的表达情况。方法采用免疫组化的方法,分别对100例轻型食管炎患者和100例食管癌患者组织中的IRBIT表达情况进行了检测,并比较了早期食管癌和中晚期食管癌的表达差别。结果IRBIT阳性表达在食管癌组低于轻度食管炎组,阴性表达高于轻度食管炎组,两组比较差异有统计学意义(P<0.05);中晚期食管癌又低于早期食管癌,差异有统计学意义(P<0.017)。结论IRBIT的表达在轻度食管炎组织中最高,其次是早期食管癌,中晚期食管癌最低,IRBIT在人类可能发挥着抑癌基因的作用。Objective To study the expression of IRBIT(IP3 receptor binding protein)in esophageal cancer.Methods Immunohistochemical methods were used to detect the expression of IRBIT in tissues of 100 patients with mild esophagitis and 100 patients with esophageal cancer,and the expression differences between early esophageal cancer and mid to late stage esophageal cancer were compared.Results The positive expression of IRBIT in esophageal cancer group was lower than that in mild esophagitis group,and the negative expression was higher than that in mild esophagitis group,and the difference was significant(P<0.05);The positive expression of IRBIT in the advanced esophageal cancer was lower than that in the early esophageal cancer,the difference was significant(P<0.017).Conclusion The expression of IRBIT was the highest in mild esophagitis tissues,followed by early esophageal cancer,and the lowest in advanced esophageal cancer.IRBIT may play a role as a tumor suppressor gene in humans.

关 键 词：轻型食管炎 早期食管癌 中晚期食管癌 IRBIT 

分 类 号：R571[医药卫生—消化系统]