靶向免疫代谢改善肿瘤微环境  

Targeting Immune Metabolism to Improve the Tumor Microenvironment

作　　者：刘谷一 周宏祎 丁剑兰 陈乐乐 孙江涛[1] LIU Gu-yi;ZHOU Hong-yi;DING Jian-lan;CHEN Le-le;SUN Jiang-tao(The State Key Laboratory of Esophageal Cancer Prevention and Control,the Key Laboratory of Microecology and Esophageal Cancer Prevention and Control of Henan Province,the First Affiliated Hospital of Henan University of Science and Technology,the Cancer Hospital of Henan Province and the Ministry of Henan University of Science and Technology,Key Laboratory of Cancer Epigenetics of Henan Province,Luoyang,China,471003)

机构地区：[1]河南科技大学临床医学院,河南科技大学第一附属医院,肿瘤医院,省部共建食管癌防治国家重点实验室,河南省微生态与食管癌防治重点实验室,河南省肿瘤表观遗传重点实验室,中国洛阳471003

出　　处：《食管疾病》2023年第4期279-284,共6页Journal of Esophageal Diseases

摘　　要：免疫代谢近年来日益受到关注,癌基因驱动的肿瘤细胞代谢变化可影响肿瘤微环境(TME),进而抑制免疫反应,并对癌症治疗造成障碍。这提示我们可以通过靶向代谢途径改善TME,增强抗癌免疫效应。本文总结目前将TME内免疫细胞代谢转变为促炎状态的策略,并强调需要更好地还原生理条件,进而选择靶点、阐明机制和优化代谢抑制剂。The growing field of immune metabolism has revealed promising indications for metabolic targets to modulate anti-cancer immunity.Oncogene-driven changes in tumor cell metabolism can impact the TME to limit immune responses and present barriers to cancer therapy.These changes also reveal opportunities to reshape the TME by targeting metabolic pathways to favor immunity.Here we explore current strategies that shift immune cell metabolism to pro-inflammatory states in the TME and highlight the need of better replicate physiologic conditions to select targets,clarify mechanisms,and optimize metabolic inhibitors.

关 键 词：免疫代谢 肿瘤微环境 食管癌 免疫治疗 

分 类 号：R735.1[医药卫生—肿瘤]