Applications of SMILE-extracted lenticules in ophthalmology  

作　　者：Hossein Aghamollaei Hassan Hashemi Mahsa Fallahtafti Seyed-Hashem Daryabari Mehdi Khabazkhoob Khosrow Jadidi 

机构地区：[1]Chemical Injuries Research Center,Systems Biology and Poisonings Institute,Baqiyatallah University of Medical Sciences,Tehran 1968653111,Iran [2]Noor Research Center for Ophthalmic Epidemiology,Noor Eye Hospital,Tehran 1983963113,Iran [3]Vision Health Research Center,Semnan University of Medical Sciences,Semnan 1914853185,Iran [4]Department of Basic Sciences,School of Nursing and Midwifery,Shahid Beheshti University of Medical Sciences,Tehran 1968653111,Iran

出　　处：《International Journal of Ophthalmology(English edition)》2024年第1期173-187,共15页国际眼科杂志（英文版）

摘　　要：AIM:To review recent innovations,challenges,and applications of small incision lenticule extraction(SMILE)extracted lenticule for treating ocular disorders.METHODS:A literature review was performed in the PubMed database,which was last updated on 30 December 2021.There was no limit regarding language.The authors evaluated the reference lists of the collected papers to find any relevant research.RESULTS:Due to the simplicity and accuracy of modern femtosecond lasers and the extensive development of SMILE surgery,many healthy human corneal stromal lenticules were extracted during surgery,motivating some professionals to investigate the SMILE lenticule reusability in different ocular disorders.In addition,new approaches had been developed to preserve,modify,and bioengineer the corneal stroma,leading to the optimal use of discarded byproducts such as lenticules from SMILE surgery.The lenticules can be effectively re-implanted into the autologous or allogenic corneas of human subjects to treat refractive errors,corneal ectasia,and corneal perforation and serve as a patch graft for glaucoma drainage devices with better cosmetic outcomes.CONCLUSION:SMILE-extracted lenticules could be a viable alternative to human donor corneal tissue.

关 键 词：small incision lenticule extraction corneal lenticule implantation KERATOCONUS corneal perforation femtosecond laser stromal keratophakia 

分 类 号：R770.421[医药卫生—眼科]