氧化石墨烯-壳聚糖用于中药派特灵膜剂载体的制备与表征  

Preparation and Characterization of Graphene Oxide-chitosan as the Carrier of Paiteling Films

作　　者：王欣[1] 施章浪 刘晓青 崔曼[2] 李媛 文继红[2] Wang Xin;Shi Zhanglang;Liu Xiaoqing;Cui Man;Li Yuan;Wen Jihong(School of Materials Science and Engineering,Jilin University,Jilin,130012;The First Hospital of Jilin University,Jilin,130021)

机构地区：[1]吉林大学材料科学与工程学院,吉林130012 [2]吉林大学第一医院,吉林130021

出　　处：《当代化工研究》2023年第22期28-31,共4页Modern Chemical Research

基　　金：吉林省发展和改革委员会项目“新型抗HPV病毒纳米载药膜的研发与应用”(项目编号:2021C043-5);吉林省科学技术厅项目“石墨烯微-纳米纤维对神经突起的导向作用及机理研究”(项目编号:20210101381JC)。

摘　　要：研究制备氧化石墨烯(GO)、壳聚糖(CS)和GO-CS复合材料,探讨其作为派特灵中药新型膜剂载体的可行性。采用傅里叶变换红外光谱和拉曼光谱表征样品的化学结构,通过紫外可见分光光度计测定派特灵的吸光度标准曲线。结果表明,采用溶液共混结合溶剂蒸发法制备的GO-CS复合膜剂的药物释放为pH敏感机制,具有缓释效应,载药率和包封率可分别高达(75.60±1.92)%和(71.12±1.56)%。本研究为研发派特灵中药新剂型提供参考,也可为开发其它中药膜剂提供参考。In this study,traditional Chinese medicine-paiteling films was developed,and the feasibility of graphene oxide(GO),chitosan(CS),and GO-CS,respectively as carrier was explored.The chemical structure of the samples was characterized by Fourier transform infrared spectroscopy and Raman spectroscopy.UV-vis absorption spectra of the samples were employed to analyze Paiteling-loading performance.The results showed that the drug release of GO-CS composite film was pH sensitive and had a sustained release effect.The highest drug loading and encapsulation efficiency was(75.60±1.92)%and(71.12±1.56)%,respectively.This study provides a reference for the development of new formulations of Paiteling traditional Chinese medicine,as well as for the development of new formulations of other traditional Chinese medicine films.

关 键 词：派特灵 人乳头瘤病毒 氧化石墨烯 壳聚糖 膜剂 制备 表征 

分 类 号：R[医药卫生]