非转基因法阿尔兹海默病动物模型的研究进展  

Research Progress on Non Transgenic Animal Models of Alzheimer's Disease

作　　者：吴殿秀 韩雨霖 袁依然 周姝婷 王海鹏[1] WU Dianxiu;HAN Yulin;YUAN Yiran;ZHOU Shuting;WANG Haipeng(Basic Medical College,Beihua university,Jilin City,Jilin Province 132013,China)

机构地区：[1]北华大学基础医学院,吉林吉林132013

出　　处：《吉林医药学院学报》2024年第1期61-64,77,共5页Journal of Jilin Medical University

基　　金：吉林省教育厅科学研究项目(JJKH20230080KJ);吉林省卫生与健康青年骨干培养计划项目(2020Q004);吉林省大学生创新项目(S202110201138,S202210201157)。

摘　　要：阿尔兹海默病(Alzheimer's,AD)是一种中枢神经系统退行性病变,由于其病理机制复杂,病因不确定,时至今日,依旧是人类疾病史上尚未攻克的难题。为更好地研究其发病机制、病理特点以及治疗方案,找到一种与人类病变特点相似的动物模型至关重要。本文综述了国内外8种非转基因法AD动物模型的制作方法,深入探讨不同AD动物模型的技术原理、病理变化特点、时效性及优缺点,以避免科学工作者重复研究,为科研创新性提供有力的支持。Alzheimer's disease(AD)is a degenerative disease of the central nervous system.Due to its complex pathological mechanism and uncertain etiology,it is still an unsolved problem in the history of human diseases.In order to better study its pathogenesis,pathologi⁃cal characteristics and treatment,it is very important to find an animal model similar to the characteristics of human lesions.This paper reviews the production methods of domestic and international 8 kinds of non transgenic animal models of Alzheimer's disease.The techni⁃cal principles,pathological changes,timeliness,advantages and disadvantages of different AD animal models are discussed in depth,so as to provide strong data support for avoiding repeated research by scientific workers and improving scientific research innovation.

关 键 词：阿尔兹海默症 动物模型 转基因 非转基因 

分 类 号：R749[医药卫生—神经病学与精神病学]