发动蛋白抑制剂dynasore的功能及在疾病治疗中的研究进展  

Progress in function of dynamin inhibitor dynasore and its role involved in treatments of diseases

作　　者：田振振 陈喆 朱平[2,4] 宋银宏[1,2,3] TIAN Zhenzhen;CHEN Zhe;ZHU Ping;SONG Yinhong(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy,China Three Gorges University,Yichang 443002,China;Institute of Infection and Inflammation,China Three Gorges University,Yichang 443002,China;College of Basic Medical Science,China Three Gorges University,Yichang 443002,China;Department of Nephrology,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China)

机构地区：[1]肿瘤微环境与免疫治疗湖北省重点实验室(三峡大学),湖北宜昌443002 [2]三峡大学感染与炎症损伤研究所,湖北宜昌443002 [3]三峡大学基础医学院,湖北宜昌443002 [4]三峡大学第一临床医学院肾病内科,湖北宜昌443003

出　　处：《中国病理生理杂志》2023年第12期2273-2279,共7页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81671397);湖北省教育厅基金资助项目(No.B2017024);宜昌市医疗卫生研究项目(No.A20-2-002)。

摘　　要：发动蛋白(dynamin)超家族存在于所有细胞生命活动中,在胞膜构成、肌动蛋白束和先天免疫等方面发挥重要作用。发动蛋白作为该家族的主要成员,是一种多结构域的机械化学鸟苷三磷酸酶(guanosine triphosphatase,GTPase)蛋白,对鸟嘌呤核苷酸具有低亲和力、高基础水解率,能自组装成高阶螺旋结构^([1]),在包膜重塑、膜裂变和跨高尔基体出芽等作用中发挥着重要作用^([2])。Dynasore is a small molecule that inhibits the GTPase activity of dynamin and mitochondria-related proteins both in vitro and in vivo,consequently preventing bacteria and viruses from entering cells via endocytic processes,impeding infection and spread of the pathogen.Dynasore is able to participate in cell survival,proliferation and apoptosis through a variety of dynamin protein-independent mechanisms such as reducing reactive oxygen species production,inhibiting ferroptosis,lowering dynamin-related protein 1 activity to reduce mitophagy,and deeply engaging in vascular endothelial growth factor pathway.Here based on the molecular mechanisms and signaling pathways of dynasore involving in diseases,this review summarizes the role of dynasore in microbial infections,neurodegenerative diseases,and tumors.

关 键 词：dynasore 发动蛋白 内吞作用 铁死亡 线粒体自噬 

分 类 号：R363.21[医药卫生—病理学] R73[医药卫生—基础医学] R741